Development of the Cerebellum from Molecular Aspects to Diseases

ISBN-13: 9783319866932 / Angielski / Miękka / 2018 / 505 str.

Hassan Marzban

Spis treści

1) A historical overview of cerebellar neurodevelopmental disorders; V. Persaud, U of Manitoba, Canada

2) Epidemiology of cerebellar disorders; S. Shooshtari, U of Manitoba, Canada

3) Cerebellar embryology, anatomy, and function; H. Bergen, U of Manitoba, Canada

4) Developmental patterns in the cytoarchitecture of the cerebellum; R. Hawkes, U of Calgary, Canada

5) Developmental disorders of the cerebellum; M. Del Bigio, U of Manitoba, Canada

6) Developmental disorders of the cerebellum and GABAergic signaling pathway; G.G. Consalez, San Raffaele Scientific Institute, Italy

7) Developmental disorders of the cerebellum and glutamatergic signaling pathway; S. Ying, Hangzhou University, China

8) Developmental disorders of the cerebellum and cerebellar nuclei neurons; R. Hevner, Seattle Children’s Research Institute, USA

9) Developmental disorders of the cerebellum and nerve growth factor signaling pathway; S. Chung, U of Illinois, Chicago, USA

10) Developmental disorders of the cerebellum and glial cells; J. Kong, U of Manitoba, Canada

11) Developmental disorders of the cerebellum and genetics; A. Joyner, New York Memorial Hospital, USA

12) Developmental disorders of the cerebellar afferent and efferent (ataxia); R. Sillitoe, Baylor College of Medicine, USA

13) Developmental disorders of the cerebellum and fetal alcohol syndrome; A. Chudley, U of Manitoba, Canada

14) Developmental disorders of the cerebellum and autism spectrum disorder; H. Fatemi, University of Minnesota Medical School, USA

15) Developmental disorders of the cerebellum and immune system malfunction; A.A. Owji, Shiraz University of Medical Sciences, Iran<

16) Developmental disorders of the cerebellum and Apoptosis, Autophagy, UPR; S. Ghavami, U of Manitoba, Canada

17) Developmental disorders of the cerebellum and ubiquitin proteasome system; J. Vriend, U of Manitoba, Canada

18) Developmental disorders of the cerebellum and mitochondrial damages; M.J. Hosseini, Zanjan University of Medical Sciences, Iran.

19) Developmental disorders of the cerebellum and tumors; T. Klonisch, U of Manitoba, Canada

20) Developmental disorders of the cerebellum and teratogen, toxin, and radiation; A. Chudley, and V Persaud, U of Manitoba, Canada

21) Developmental disorders of the cerebellum and endocrine diseases; N. Koibuchi, Gunma University, Japan

22) Developmental disorders of the cerebellum and infectious diseases; K. Coombs, U of Manitoba, Canada

23) Animal models for the study of developmental disorders of the cerebellum; D. Goldowitz, U of British Columbia, Canada

24) Neuroimaging and cerebellar disorder; K.J. Millen, Seattle Children's Hospital, USA

25) Diagnosis, Clinical Symptoms,

O autorze

Dr. Hassan Marzban (Editor) is a human anatomist and cerebellar developmental biologist, at Department of Human Anatomy and Cell Sciences,  the College of Medicine, Faculty of Health Sciences, University of Manitoba. Dr. Marzban is a pioneer in the field and his research is focused to understand the cellular and molecular mechanisms of the developing cerebellum and neurodevelopmental disorders and disabilities.

Blurb

The authors present the most current and cutting-edge knowledge regarding the molecular basis of cerebellar development, focusing on information relevant to laboratory scientists and clinicians providing service to patients with cerebellar disorders. Knowledge obtained from advanced neuroimaging techniques that are used during development, and from molecular- and genetic-based studies has provided rapidly-growing evidence that the cerebellum is a brain region that is highly impacted by developmental defects. Cerebellar defects result in significant intellectual and motor function impairment that affects both the patients and their families.