Design, Synthesis and Evaluation of Some Novel Heterocyclic Compounds

ISBN-13: 9783659873072 / Angielski / Miękka / 2016 / 84 str.

Parag Rabara; Shashikant Pattan

Opis

In the present research work a new series of 1,3,4-oxadiazole & pyrazolone derivatives have been synthesized. 2-mercapto-1,3,4-oxadiazole derivatives were synthesized by reacting corresponding acid hydrazide with carbon disulfide followed by condensing the active hydrogen atom of 2-mercapto group of 5-aryl-2-mercapto-1,3,4-oxadiazole with 2-chloro pyridine, 4-chloro aniline & epichlorohydrine to give 5-aryl-2-(substituted aryl ylthio)-1,3,4-oxadiazole derivatives(A1-3, B1-4). 5-(substituted aryl)-1,3,4-oxadiazole derivatives were synthesized by reacting salicylic acid hydrazide with aromatic acid to give 5-(2-hydroxy phenyl)-2-aryl-1,3,4-oxadiazole derivatives (A4-6): 3-methyl-pyrazol-5(4H)-one derivatives were synthesized by reacting corresponding acid hydrazide with ethyl acetoacetate to give 1-(substituted aryl)-3-methyl-1H-pyrazol-5(4H)-one. Followed by condensing the active hydrogen atom of -CH2- of pyrazolone with Isonicotinic acid hydrazine/ p-amino salicylic acid/ sulfanilamide / 5-amino tetrazole / pyrazinoic acid hydrazide / 2-amino pyrazine to give corresponding pyrazolone derivatives (A7-11, B5-9).

O autorze

Prof. Parag A. Rabara is working as a Associated Professor at Atmiya Institute of Pharmacy, Rajkot, Gujarat, India. He has 08 years of teaching experience in B. Pharm. He has published more than 09 research papers and review article in various National and International Journals.