Dermatopharmacology of Topical Preparations: A Product Development-Oriented Approach

ISBN-13: 9783642629600 / Angielski / Miękka / 2012 / 470 str.

B. Gabard; P. Elsner; C. Surber

Opis

Proof of the efficacy of dermatological products is a prerequisite for clinical testing and registration. Now, efficacy claims for cosmetics must be equally substantiated. This book provides a concise, practical but comprehensive overview of experimental models used to screen, develop and select dermatological and cosmetic formulations. The authors are recognized specialists in their field and use a standardized approach to the projects facilitating the reading for the stressed scientist, for the R]D managers general view as well as for the beginners in the field.

Spis treści

General.- 2 The Vehicle: The Pharmaceutical Carrier of Dermatological Agents.- 3 The Absolute Fundamentals of Transdermal Permeation (Drug Delivery for Dummies).- 4 Basics (Guidelines) on Cell Culture Testing for Topical Dermatological Drugs/Products and Cosmetics With Regard to Efficacy and Safety of the Preparations.- 5 Guidelines and Methods on Safety Testing for Dermatics and Cosmetics.- 6 Basics on Clinical Safety Testing.- Projects.- 7 Antimicrobials.- 8 Topical Antifungal Agents.- 9 Hand Disinfection and Antiseptic of Skin, Mucous Membranes, and Wounds.- 10 Antivirals.- 11 Dermatopharmacology of Antiparasitics and Insect Repellents.- 12 Antiphlogistics (Dermocorticoids and topical immunomodulators).- 13 Antiseborrheics.- 14a Principle of Drug Treatments for Itch.- 14b Methodological Approaches for Testing Anti-Itch and Related Substances.- 15 Hair: Scalp Hair Growth Evaluation Methods.- 16 Keratolytics.- 17 Dermatopharmacology of Topical Anti-Fungal Preparations in Nail Tissue.- 18 Skin Care/Detergents.- 19 Skin Hydration.- 20 Efficacy of Skin Care Products and Different Mixtures of Lipids on Barrier Function.- 21 Project Sunscreen Protection.- 22 Photoaging - Retinoids, Alpha Hydroxy Acids, and Antioxidants.- 23 Antiperspirants.- 24 Wound Healingo.- 25 Marketing of Pharmaceutical Products.

O autorze

The concept of this book is within the frame of dermatological product development as a prerequisits for clinical and registration of a given topical preparation. Additionally, efficacy claims for cosmetics must now be supported, and the book will also consider this aspect of formulation development.