Dementia and Motor Neuron Disease

ISBN-13: 9780415391665 / Angielski / Twarda / 2006 / 86 str.

Michael J. Strong; Strong J. Strong; Michael J. Strong

Opis

Amyotrophic lateral sclerosis (ALS)--also termed "motor neuron disease" or "Lou Gehrig's disease"--is a common disorder and a number of texts have appeared over the last several years regarding either its clinical or biological characteristics. However, there are no existing texts that discuss the clinical, neuroimaging, neuropathological and neurochemical characteristics of dementia in ALS. This is in spite of the increasing evidence that dementias occur in ALS and that they share many features in common with a frontotemporal lobar degeneration. The importance of this is highlighted by the increasing interest in frontotemporal lobar degeneration as a major cause of dementia in the aging population, in some studies exceeding that of Alzheimer's disease. Moreover, there is a considerable spectrum of cognitive impairment in ALS, with recent estimates suggesting that almost two-thirds of ALS patients will have some degree of frontal cognitive or behavioural impairment. This represents a dramatic shift in our conceptualization of ALS as a purely motor system selective disorder. This text will provide a single authorative reference on the current understanding of frontotemporal dementia in ALS and will find a broad market in the neurosciences field. Because of the crossover between the dementias and motor neuron diseases, this will be applicable to both clinical and research groups focusing on either dementia or ALS. The design of the book and the topics selected will also find broad applicability to neuroimaging and neuropsychology. The intent is to have this as a true reference standard to established clinicians and researchers, as well as graduate students studying neurodegeneration.

Spis treści

Foreword by Andrew Kertesz 1. Frontotemporal Dementia in ALS: Lessons from History  2. Frontotempotral Dementia – Current Concepts  3. Clinical Phenomenology and Treatment of Frontotemporal Dementia  4. The Clinical and Pathological Spectrum of ALS  5. Identification and Categorization of Frontotemporal Impairment in ALS  6. The Spectrum of Altered Cognition in Amyotrophic Lateral Sclerosis  7. The Spectrum of Cognitive Dysfunction in ALS/MND in the Japanese Population  8. Primary Lateral Sclerosis: Cognitive, Language, and Cerebral Hemodynamic Findings  9. The Anatomic Basis of Symptoms in Frontotemporal Dementia  10. Neuroimaging in ALS and ALS with Frontotemporal Dementia  11. New Approaches to Imaging in ALS  12. Neuropathology of Frontotemporal Lobar Degenerations  13. Molecular and Cellular Neuropathology of Cognitive Dysfunction in ALS  14. Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex of Guam  15. Neuropathology of the Japanese Variants of FTD/ALS  16. The Genetics of Frontotemporal Dementia  17. Frontotemporal Dementia and the Involvement of Tau  18. Altered Tau Protein Metabolism in Amyotrophic Lateral Sclerosis with Cognitive Impairment  19. Frontotemporal Syndromes in the Motor Neuron Diseases

O autorze

Michael J Strong MD FRCPC is Professor and Co-Chair, Department of Clinical Neurological Sciences, University of Western Ontario and Scientist, Cell Biology Research Group, Robarts Research Institute, London, ON, Canada