Delivery Strategies for Antisense Oligonucleotide Therapeutics

ISBN-13: 9781138558571 / Angielski / Miękka / 2019 / 318 str.

UK) Saghir Akhtar (Cardiff University

Opis

With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.

Spis treści

1. Preface 2. Overview of antisense oligonucleotide therapeutics and delivery 3. Disrupting the flow of genetic information with antisense oligodeoxynucleotides: research and therapeutic applications 4. Cellular delivery of ribozymes 5. Improved structural design and cellular 6. Uptake of gt-rich triplex-forming oligonucleotides 7. Pharmacokinetic and distribution studies 8. Pharmacokinetics and delivery of oligonucleotides to the brain 9. In vivo pharmacokinetics of oligonucleotides following administration by different routes 10. Improving biological stability of oligonucleotides 11. Nuclease-resistant nucleic acid therapeutics 12. Self-stabilized oligonucleotides as novel antisense agents 13. Circular oligonucleotides as potential modulators of gene expression 14. Peptide nucleic acids as antisense therapeutic agents 15. Stabilized rna analogues for antisense and ribozyme applications 16. Improving membrane transport and targeted delivery of antisense oligonucleotides 17. Uptake and localization of phosphodeister and chimeric 18. Oligodeoxynucleotides in normal and leukaemic primary cells 19. Oligonucleotide transport across membranes and into cells: effects of chemical modifications 20. Liposomes as a delivery system for antisense and ribozyme compounds 21. Intracellular delivery of oligonucleotides with cationic liposomes 22. The delivery of oligonucleotides using ph-sensitive liposomes 23. Enhancing endsosomal exit of nucleic acids using ph-sensitive viral fusion peptides 24. Targeted delivery of anti-hepatitis b antisense oligonucleotides 25. Design, synthesis, and cellular delivery of antibody antisense oligonucleotide conjugates for cancer therapy