1. An introduction to the defense-related proteins in plants 2. Origin, classification and evolutionary history of defense-related proteins in plants 3. Pathogenesis-related proteins and plant defense-response 4. Role of thaumatin-like proteins in plants 5. Plants chitinases: Role in biotic stress response 6. Structural and functional diversity of plant lectins 7. Plant protease inhibitors; biological roles and applications in plant stress tolerance 8. Osmotin in stress response and signaling in plants 9. Defensins in plants: Diversity and role in plant defense 10. NBS-LRRs: Role in defense signaling 11. Structural and functional significance of RLKs and RLCKs in plant defense response 12. Role of Heat shock proteins in abiotic and biotic stress response in plants 13. Late Embryogenesis Abundant (LEA) proteins: Role in development and defense response in plants 14. Insight into the role of Extensins in plant defense response 15. Pectin Methylesterase (PME) and PME Inhibitors (PMEIs): Exploration of their role in stress response in plants 16. Role of Thionins in biotic stress tolerance in plants 17. Functional divergence in Plant Cyclotides and their role in plant defense 18. Enzymatic antioxidants in stress response and signaling in plants 19. Role of calcium-binding proteins in defense signaling in plants 20. Application of defense-related proteins in crop improvement strategies: A future perspective