Death Receptors in Cancer Therapy

ISBN-13: 9781588291721 / Angielski / Twarda / 2004 / 374 str.

Wafik S. El-Deiry

Opis

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Recenzje

From the reviews:

"The book is resourceful for both basic scientists and clinicians, who are interested in developing targeted therapies for cancer. ... the book is a valuable tool for researchers as well as to those of us involved in teaching apoptosis to undergraduate and graduate students." (Harikrishna Nakshatri, Leukemia Research, 2005)

Spis treści

Mammalian Cell Death Pathways: Intrinsic and Extrinsic E. Robert McDonald III and Wafik S. El-Deiry Resistance to Apoptosis in Cancer Therapy David J. McConkey Structures of TNF Receptors and Their Interactions With Ligands Sarah G. Hymowitz and Abraham M. de Vos Death Receptor Signaling in Embryonic Ectodermal Development Preet M. Chaudhary Adaptor Proteins in Death Receptor Signaling Nien-Jung Chen and Wen-Chen Yeh Caspase Activation by the Extrinsic Pathway Xiaolu Yang Death Signaling and Therapeutic Applications of TRAIL Mi-Hyang Kim and Dai-Wu Seol Death Receptor Mutations Sug Hyung Lee, Nam Jin Yoo, and Jung Young Lee Regulation of Death Receptors Udo Kontny and Heinrich Kovar Regulation of TRAIL Receptor Expression in Human Melanoma Peter Hersey, Si Yi Zhang, and Xu Dong Zhang Regulation of Death Receptors by Synthetic Retinoids Shi-Yong Sun Role of p53 in Regulation of Death Receptors Rishu Takimoto Proapoptotic Gene Silencing Via Methylation in Human Tumors Tanya Tekautz, Tal Teitz, Jill M. Lahti, and Vincent J. Kidd Regulation of Death Receptor-Induced Apoptosis by NF-kB and Interferon Signaling Pathways: Implications for Cancer Therapy Rajani Ravi and Atul Bedi TRAIL in Cancer Therapy Mahaveer Swaroop Bhojani, Brian D. Ross, and Alnawaz Rehemtulla Expression and Regulation of Death Receptors in Multiple Myeloma and Prostate Carcinoma Subrata Ray, John G. Hissong, Marcela Oancea, and Alex Almasan Regulation of TRAIL-Induced Apoptosis by Transcriptional Factors Rüdiger Göke and Youhai H. Chen Sensitizing Tumor Cells by Targeting Death Receptor Signaling Inhibitors Christina Voelkel-Johnson Ceramide, Ceramidase, and FasL Gene Therapy in Prostate Cancer James S. Norris,David H. Holman, Marc L. Hyer, Alicja Bielawska, Ahmed El-Zawahry, Charles Chalfant, Charles Landen, Stephen Tomlinson, Jian-Yun Dong, Lina M. Obeid, and Yusuf Hannun Gene Therapy Targeting Receptor-Mediated Cell Death to Cancers Lidong Zhang and Bingliang Fang Combination of Chemotherapy and Death Ligands in Cancer Therapy Simone Fulda and Klaus-Michael Debatin Index

O autorze

Wafik S. El-Deiry, M.D., Ph.D, is Professor of Medicine, Chief, Hematology/Oncology, Rose Dunlap Division Chair in Hematology/Oncology, and Associate Director for Translational Researchat Penn State Hershey Cancer Institute. Dr. El-Deiry is a well-respected and notable figure among cancer researchers, scientists, and clinicians. He has published almost 300 papers in his career and has over 29,000 totol citations, with an excellent h-index of 70.

Blurb

Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.
Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.