DNA Tumor Viruses

ISBN-13: 9781493950591 / Angielski / Miękka / 2016 / 798 str.

James Pipas; Damania Blossom; Blossom Damania

Opis

This book focuses on the DNA viruses in the human population that are associated with cancers. It covers most of the viruses that are thought to contribute to human malignancy. The book represents a comprehensive review of the field of DNA tumor virology.

Spis treści

INTRODUCTION James Pipas and Blossom Damania CHAPTER 1 Polyomavirus Life Cycle Ellen Fanning, Xiaorong Zhao, and Xiaohua Jiang CHAPTER 2 Transformation by Polyomaviruses Dweepanita Das and Michael J. Imperiale CHAPTER 3 Polyomaviruses and Disease Jaime M. Kean and Robert L. Garcea CHAPTER 4 The Life Cycle of Human Papillomaviruses Cary A. Moody and Laimonis A. Laimins CHAPTER 5 Papillomavirus Transformation Kimberly Johung and Daniel DiMaio CHAPTER 6 Papillomaviruses: Biology, Diversity and Pathogenesis. Hans Uli Bernard CHAPTER 7 Adenovirus Transformation Patrick Hearing CHAPTER 8 Overview of the Large DNA Tumor Viruses Subhash C. Verma, Qiliang Cai, Bharat G. Bajaj and Erle S. Robertson CHAPTER 9 Epidemiology of EBV Infection Rosemary Rochford CHAPTER 10 Epstein-Barr Virus Diseases Joseph S. Pagano CHAPTER 11 The EBV Viral Genome Jeffrey Sample and Clare Sample CHAPTER 12 Epstein Barr Virus Transforming Proteins: Biologic Properties and Contribution to Oncogenesis Nancy Raab-Traub CHAPTER 13 The Epstein-Barr Virus Lytic Lifecycle Sankar Swaminathan and Shannon Kenney CHAPTER 14 Epstein-Barr Virus Latent Infection Nuclear Proteins; Genome maintenance and regulation of lymphocyte cell growth and survival Eric Johannsen, Michael Calderwood, Myung-Soo Kang, Bo Zhao, Daniel Portal, and Elliott Kieff CHAPTER 15 Epstein-Barr Virus Entry Richard Longnecker, Lindsey Hutt-Fletcher, Ted Jardetzky CHAPTER 16 Epstein-Barr Virus Immunotherapy Leslie E. Huye and Cliona M. Rooney CHAPTER 17 Kaposi’s Sarcoma-associated Herpesvirus Epidemiology and Subtype Evolution Gary S. Hayward and Denise Whitby CHAPTER 18 Introduction to diseases associated with Kaposi’s Sarcoma-associated Herpesvirus Patrick S. Moore and Yuan Chang CHAPTER 19 Organization and Expression of the Kaposi’s Sarcoma-associated Herpesvirus Genome Yan Yuan and Rolf Renne CHAPTER 20 Kaposi’s Sarcoma-associated Herpesvirus latent genes and their regulation Dirk P. Dittmer CHAPTER 21 Regulation of Expression, Mode of Action and Downstream Targets of ORF50 Protein in KSHV Lytic Cycle Activation. Pey-Jium Chang, Jianjiang Ye, and George Miller. CHAPTER 22 HHV-8/KSHV proteins involved in signaling and transformation Silke Hartmann, Thomas F. Schulz, and John Nicholas CHAPTER 23 Kaposi’s Sarcoma-associated Herpesvirus entry and infection of target cells Bala Chandran and Neelam Sharma-Walia CHAPTER 24 Kaposi’s Sarcoma-associated Herpesvirus Immune Evasion Chengyu Liang, Hyera Le, Liguo Wu, Pinghui Feng, and Jae U. Jung CHAPTER 25 Non-coding regulatory RNAs of the DNA Tumor viruses Christopher S. Sullivan and Bryan R. Cullen CHAPTER 26 AIDS and associated malignancies William J. Harrington, Jr. and Charles Wood CHAPTER 27 Primate Models for Gammaherpesvirus-associated Malignancies Ilhem Messaoudi, Blossom Damania and Scott W. Wong CHAPTER 28 Murine Gammaherpesvirus 68 Infection of Mice: a Small Animal Model for Characterizing Basic Aspects of Gamma-herpesvirus Pathogenesis James Craig Forrest, Laurie T. Krug, and Samuel H. Speck

Blurb

The DNA tumor viruses are central to many branches of molecular and cellular biology. This very diverse group of viruses attack common cellular pathways, which makes them powerful tools for understanding how multiple complex pathways are integrated. Additionally, the unique mechanisms employed by each viral system to alter cellular functions serve as powerful molecular probes for the identification of new targets and pathways. The scientific impact of the DNA tumor viruses extends far beyond their etiologic role in human cancers, or their contributions to our basic understanding of the cellular pathways that drive tumorigenesis. Currently, research on these viruses lies at the interface of cancer and the innate and adaptive immune response, investigating how infectious agents influence, evade, and utilize systems that regulate these processes. Thus, DNA tumor viruses serve as models for the systems biology of host-pathogen interactions.

"DNA Tumor Viruses," edited by Blossom Damania and James M. Pipas, summarizes recent advances in our understanding of this diverse and fascinating collection of viruses.