DNA Repair and Recombination

ISBN-13: 9789401042390 / Angielski / Miękka / 2012 / 103 str.

T. R. Lindahl; S. C. West

Opis

The processes of DNA repair and recombination are currently of widespread interest. This book, which arises from a Royal Society discussion meeting, presents an authoritative and very comprehensive overview of the subject by the leading researchers in the field. Key topics discussed include initiation, control and detailed mechanism of homologous recombination, V(D)J recombination and site-specific recombination, regulation and mechanisms of gene amplification and the role of nucleotide excision repair proteins in repairing DNA damage.

Recenzje

...the whole book which provides an excellent starting point for anyone interested in these topics. - Heredity

Spis treści

RecA protein mediates homologous recognition via non-Watson-Crick bonds in base triplets. The initiation and control of homologous recombination in Escherichia coli. Formation, translocation and resolution of Holliday junctions during homologous genetic recombination. Structure of the four-way DNA junction and its interaction with proteins. Site Specific recombination and circular chromosome segregation. Steps along the pathway of V(D)J recombination. Regulation and mechanisms of gene amplification. Enzymes acting at strand interruptions in DNA. Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription. Proteins that participate in nucleotide excision repair of DNA in mammalian cells. Nucleotide excision repair syndromes: molecular basis and clinical symptoms. On the regulation of the p53 tumour suppressor, and its role in the cellular response to DNA damage. Mismatch repair, genetic stability and tumour avoidance. Editing DNA replication and recombination by mismatch repair: from bacterial genetics to mechanisms of predisposition to cancer in humans.