DNA Microarrays and Related Genomics Techniques: Design, Analysis, and Interpretation of Experiments

ISBN-13: 9780824754617 / Angielski / Twarda / 2005 / 390 str.

Jode W. Edwards; T. Mark Beasley; Grier P. Page

Opis

Aimed both at genetic investigators conducting analyses of microarray data and methodologists evaluating existing and developing future microarray methodologies, this volume compiles existing methodologies and methodological issues of DNA microarrays and other genomic techniques. The editors (of the Department of Biostatistics at the U. of Alabama

Spis treści

Microarray Platforms and Blood Samples. Normalization of Microarray Data. Microarray Quality Control and Assessment. Epistemological Foundations of Statistical Methods for High-Dimensional Biology. The Role of Sample Size on Measures of Uncertainty and Power. Pooling Biological Samples in Microarray Experiments. Designing Microarrays for the Analysis of Gene Expressions. Overview of Standard Clustering Approaches for Gene Microarray Data Analysis. Cluster Stability. Dimensionality Reduction and Discrimination. Modeling Affymetrix Data at the Probe Level. Parametric Linear Models. The Use of Nonparametric Procedures in the Statistical Analysis of Microarray Data. Bayesian Analysis of Microarray Data. False Discovery Rate and Multiple Comparison Procedures. Using Standards to Facilitate Interoperation of Heterogeneous Microarray Databases and Analytic Tools. Post-Analysis Interpretation: What Do I Do with This Gene List? Combining High Dimensional Biological Data to Study Complex Diseases and Quantitative Traits.

O autorze

David B. Allison, Grier P. Page, T. Mark Beasley, Jode W. Edwards