Cytoskeleton of the Nervous System

ISBN-13: 9781441967862 / Angielski / Twarda / 2011 / 774 str.

Ralph A. Nixon; David Yuan

Opis

This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more detailed descriptions of particular components, including microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein. The later chapters focus on the functional significance of the neuronal cytoskeleton in axonal transport and its regulation in health and disease states. The Cytoskeleton of the Nervous System will encourage further development of unifying principles and stimulate new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease.

Spis treści

Chapter 1: Central Axonal Development and Pathology in Early Life Robin L. Haynes, Hannah C. Kinney Chapter 2: Microtubules in the nervous system Nobuyuki Fukushima Chapter 3: Tau phosphorylation Jesús Avila, Félix Hernández Chapter 4: Tau Pathology Nicolas Sergeant, Luc Buée Chapter 5: Tauopathy and brain aging Akihiko Takashima Chapter 6: Microtubule-associated protein 4 Kiyotaka Tokuraku, Kazuyuki Matsushima, Hiroyuki Nakagawa, Susumu Kotani Chapter 7: Structure of Neural Intermediate Filaments David A.D. Parry Chapter 8: Alpha-internexin: the Fourth Subunit of Neurofilaments in the Mature CNS Aidong Yuan, Ralph A. Nixon Chapter 9: Peripherin Pathology Jesse R. McLean, Janice Robertson Chapter 10: Neurofilament cross-bridge: a structure associated specifically with the neurofilament among the intermediate filament family Takahiro Gotow Chapter 11: Neurofilament Transport Andrew J Grierson and Christopher C.J Miller Chapter 12: Knockout models of neurofilament proteins Rodolphe Perrot, Jean-Pierre Julien Chapter 13: Neurofilaments and Radial Growth: Deconstruction of a hypothesis through the construction of gene targeted mice Michael L. Garcia, Devin M. Barry Chapter 14: Deregulation of Cytoskeletal Protein Phosphorylation and Neurodegeneration Jyotshnabala Kanungo, Ya-li Zheng, Parvathi Rudrabhatla, Niranjana D. Amin, Bibhutibhushan Mishra, Harish C. Pant Chapter 15: Neurofilaments in Aged Animals Shin-ichi Hisanaga, Takahiro Sasaki, Atsuko Uchida Chapter 16: Neurofilament changes in Multiple Sclerosis Elizabeth Gray, Alastair Wilkins Chapter 17: Intermediate filament interactions in neurons Kevin G. Young, Rashmi Kothary Chapter 18: Tropomyosins in Neuronal Morphogenesis and Development Nikki Margarita Curthoys, Peter William Gunning, Thomas Fath Chapter 19: The Driving Machinery for Growth Cone Navigation Takuro Tojima, Hiroyuki Kamiguchi Chapter 20: Glial Fibrillary Acidic Protein: The intermediate filament protein of astrocytes Douglas L. Eng, Lawrence F. Eng Chapter 21: Axonal Transport Mechanisms in Cytoskeleton Formation and Regulation Aidong Yuan, Ralph A. Nixon Chapter 22: Axonal transport and motor neuron disease Anna-Lena Ström, Lawrence J. Hayward, Edward J. Kasarskis, Haining Zhu Chapter 23: In vivo imaging of axonal transport in aging and Alzheimer's disease Donna J. Cross, Satoshi Minoshima Chapter 24: Regulation of Cytoskeletal Composition in Neurons: Transcriptional and Post-transcriptional Control in Development, Regeneration, and Disease Ben G. Szaroa, Michael J. Strong Chapter 25: Crosstalks between myelinating cells and the axonal cytoskeleton Rodolphe Perrot, Joël Eyer Chapter 26: Topographic regulation of neuronal intermediate filament proteins by phosphorylation: In health and disease Parvathi Rudrabhatla, Harish C Pant Chapter 27: Cytoskeleton, axonal transport, and the mechanisms of axonal neuropathy Hsinlin T Cheng, Brian Callaghan, Jacqueline R Dauch and Eva L Feldman Chapter 28: Effects of Insulin on Tau and Neurofilament R. Schechter, K.E. Miller Chapter 29: Ethanol effects on the cytoskeleton of nerve tissue cells Sergio G. Evrard, Alicia Brusco

O autorze

Ralph A. Nixon is the Director of Silberstein Institute and Center of Excellence on Brain Aging; a Professor of Psychiatry and Cell Biology at NYU Langone Medical Center; the Director of Research and The Center for Dementia Research at Nathan S. Kline Institute for Psychiatric Research. Aidong (David) Yuan is the Research Project Manager at the Center for Dementia Research, Nathan S. Kline Institute; a Research Assistant Professor of Psychiatry at New York University Langone Medical Center and New York University School of Medicine.

Blurb

Without a cytoskeleton, a neuron or glial cell would be a shapeless jelly mass unable to function in the milieu of the brain. If we are to understand neuronal cells function in health and disease, we must determine how the cytoskeleton forms and contributes to neural physiology and pathobiology. Cytoskeleton of the Nervous System provides a comprehensive, authoritative and up-to-date account of what we now know and what we want to know in the near future--about the functioning of the cytoskeleton of neuronal cells at the molecular level. In lively accounts, which are unafraid to address controversy, Cytoskeleton of the Nervous System introduces readers to the most sophisticated concepts and latest discoveries: from overexpression systems to knock-out models for specific cytoskeletal proteins, from continuous transport assays in vivo to live-cell imaging in primary neurons, and from factors regulating cytoskeleton behavior to the dysregulation of these processes leading to neurological disease.