Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications

ISBN-13: 9781588294678 / Angielski / Twarda / 2007 / 366 str.

Robert V. House; Jacques Descotes

Opis

Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications explores the role of cytokines in immunotoxicology and human health using a variety of complex methods, from basic research to highly applied therapeutic applications. The first section of the book is devoted to basic concepts of cytokine biology, especially as this relates to the practice of immunotoxicology. Chapters in this section review the ability of external influences to modify the expression, production, and activity of these molecules. The second section provides a broad understanding of the range of cytokine activity in human disease, describing methods for assessing cytokine immunotoxicity. In the third and final section of the book, the increasingly important use of cytokines as therapeutics is explored in detail. This section includes examinations into the effects of cytokines on the immune system and in treating cancer. Timely and comprehensive, Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications will serve as both a primer and a starting point for a more detailed investigation of the role these fascinating biological regulators play in human health and disease.

Recenzje

"...unique in the way it ties together several different areas of immunology in the context of the roles of cytokines within various pathophysiological conditions and therapies...a useful reference for those interested in cytokine research." -Doody's Book Review, Weighted Numberical Score: 88 - 3 Stars

 

"...an interesting overview of the applications and role of cytokines  in human health and disease, and with large numbers of reference supplied with each chapter it is most certainly a good source of reference material for researchers in the field." -Immunology News

"This book is the latest addition to the 'Methods in Pharmacology and Toxicology' series ... . The editors, Robert House and Jacques Descotes, are internationally renowned experts in the immunotoxicology field ... . Overall, this is a useful volume, which should serve as a good reference source for toxicologists and immunologists working in the immunotoxicology and/or biopharmaceutical fields. The various chapters are concisely written and well referenced ... ." (Peter Ryle, BTS Newsletter, Winter 2007)

Spis treści

CYTOKINES IN HUMAN HEALTH: IMMUNOTOXICOLOGY, PATHOLOGY AND THERAPEUTIC APPLICATIONS Robert V. House and Jacques Descotes, Editors Table of Contents: Final Preface (Robert V. House, DVC LLC) Chapter 1: Introduction to cytokines as targets for immunomodulation (Theresa Whiteside) Chapter 2: Cytokine measurement tools for immunotoxicology (Rob J. Vandebriel) Chapter 3: The relevance of the T1/T2 paradigm in immunotoxicology: example of drug hypersensitivity reactions (Herve Lebrec and John Vasilakos) Chapter 4: Microbial exploitation and subversion of the human chemokine network (James Pease) Chapter 5: The use of cytokines in the identification and characterization of chemical allergens (Rebecca Dearman and Ian Kimber) Chapter 6: Inflammatory cytokines and lung toxicity (Debra L. Laskin, Vasanthi R. Sunil, Robert J. Laumbach and Howard M. Kipen) Chapter 7: Cytokine polymorphisms and relationship to disease (Berran Yucesoy, Victor Johnson, Michael Kashon and Michael Luster) Chapter 8 : Effects of drugs of abuse on cytokine responses (Stephen B. Pruett) Chapter 9: Preclinical approaches for safety assessment of cytokines (Peter T. Thomas and Melissa S. Beck-Westermeyer) Chapter 10: The flu-like syndrome and cytokines (Jacques Descotes and Thierry Vial) Chapter 11 : Cytokine-induced vascular leak syndrome (Roxana Baluna) Chapter 12 : Cytokines and autoimmune diseases: from the control of autoimmune diseases with anti-cytokine treatment to the induction of autoimmunity with cytokine treatment (Pierre Miossec) Chapter 13: Evaluation of antibodies in clinical trials of cytokines (Steven Swanson) Chapter 14: Cytokines and pharmacokinetic drug interactions (Kenneth Renton) Chapter 15 : Evaluation of the immunologic effects of cytokines administered to patients with cancer (Michael Robertson) Chapter 16: Clinical adverse effects of cytokines on the immune system (Thierry Vial and Jacques Descotes)