Cytokines in Hemopoiesis, Oncology, and AIDS II

ISBN-13: 9783540552420 / Angielski / Miękka / 1992 / 800 str.

Mathias Freund; Hartmut Link; Reinhold E. Schmidt

Opis

Covering a wide range of recent research developments, from basic research to clinical applications, this volume provides an overview of the biological role of cytokines as well as experiments with new cytokines. It should benefit immunologists who are developing therapeutic methods.

Spis treści

and Overview.- Cytokine Interactions in Hematopoiesis: An Introduction and Overview.- The Role of Colony-Stimulating Factors in Infection.- Physicochemical and Pharmacological Characterization of Interleukin-4: Implications for Clinical Utility.- Interleukin-10: An Overview.- Preclinical and In Vitro Data.- Colony-Stimulating Factors and Hematopoietic Cells.- In Vitro Modifications Induced by Granulocyte-Macrophage Colony-Stimulating Factor in Human Long-Term Bone Marrow Cultures.- The Addition of Granulocyte-Macrophage Colony-Stimulating Factor to Normal Bone Marrow Enhances Cell Cycle and Clonogenicity Irrespective of Cryopreservation.- Effect of Biological Response Modifiers on Human Bone Marrow Progenitor Cells in Human Immunodeficiency Virus Infection.- Plasma Erythropoietic Activity and Hemopoiesis in Murine Postnatal Ontogenesis.- In Vitro Modulation of Granulocyte-Macrophage Colony-Stimulating Factor Induced Granulocyte Surface Markers by Pentoxifylline.- Myeloperoxidase: Gene Demethylation and Expression in Acute Myeloid Leukemias.- Transduction of Neo+ Gene into Stromal Precursor Cells of Hematopoietic Microenvironment by Retroviral Gene Transfer.- Cytokines in Tumor Development and Suppression.- Cytokine Involvement in Tumor Development and Tumor Suppression.- Modulation of Growth of a Xenotransplanted Human Colon Adenocarcinoma Cell Line in Nude Mice Under the Influence of Systemic Recombinant Human GM-CSF.- Influence of Interleukin-3, Granulocyte-Macrophage Colony-Stimulating Factor, and Granulocyte Colony-Stimulating Factor on the Proliferation of Human and Murine Urothelial Tumor Cell Lines.- Different Cytokines with Autocrine and Immunosuppressive Activities are Secreted by a Small-Cell Lung Cancer Cell Line.- Effects of Recombinant Human Erythropoietin on Clonogenic Growth of Primary Human Tumor Specimens in Vitro.- Growth-Modulation Effects of Interleukin-1?, Interleukin-1?, and Macrophage Colony-Stimulating Factor in Clonogenic Tumor Cells In Vitro.- Effects of Interleukin-4, Interleukin-5, and Interleukin-7 on Clonogenic Growth of Primary Human Tumors In Vitro.- Effects of Interleukin-6 on Soft Agar Colony Formation of Primary Solid Tumor Specimens.- Chronic Lymphocytic Leukemia B Cells Express and Secrete Significant Amounts of Transforming Growth Factor-?.- In Vitro Tumor Necrosis Factor and Interleukin-1 Production in Patients with Chronic Lymphocytic Leukemia.- Effects of Tumor Necrosis Factor-? on Acute Myeloid Leukemia Cells Measured by Flow Cytometric Detection of Bromodeoxyuridine Incorporation.- Mitogenic Effect of Human Stem Cell Factor Alone or in Combination with G-CSF, GM-CSF, and IL-3 on Fresh Leukemic Blasts from Patients with Stem Cell Factor Receptor-Positive Acute Myeloid Leukemia.- Effect of Interleukin-3 in Human Hematopoietic Progenitor and Precursor Cells in Patients with Myelodysplastic Syndromes.- Differential Response of Cytogenetically Abnormal Cell Clones in Myelodysplastic Syndromes to Cytokines In Vitro.- The In Vitro Effect of Interferon-? on Chronic Myeloid Leukemia Cells.- Simultaneous Measurement of Immunophenotype and DNA Content of Bone Marrow Cells.- Cytokines in Hodgkin’s Disease.- The Expression Pattern of Cytokine Genes and Cytokine Receptors by Hodgkin’s Disease-Derived Cell Lines HDLM-2 and KM-H2 Resembles That of Activated T Cells.- Cytokine Receptors.- Tumor Necrosis Factor and Lymphotoxin-Induced Signal Pathways.- Tumor Necrosis Factor Receptor Expression on Human Normal and Malignant B Lymphocytes: Anti-75-kDa Tumor Necrosis Factor Receptor Antibody Inhibits B-Cell Proliferation.- Detection of Point Mutations Within the Macrophage Colony-Stimulating Factor Receptor Gene in Myelodysplastic Syndromes and Acute Myelomonocytic Leukemias.- Interleukin-2 Activates Nuclear Factor kB Binding Activity and Autoregulates Transcriptional Activity of its Own Receptor Gene by Normal Human Monocytes Engaging Nuclear Factor kB.- Interleukin-4 Downregulates Expression of c-kit mRNA and YB5. B8 Antigen (Stem Cell Factor Receptor) in Human Myeloid/Mast Cell Progenitor Cells.- Biochemical Characterization and Regulation of Expression of the Binding Protein for the Granulocyte Colony-Stimulating Factor on Leukemia Cells.- Tetrahydrobiopterin is a Feedback Modulator of the Interleukin-2 Receptor Complex: Manifestations and Mechanisms.- Receptor Cross-Talk: Protein Kinase C Dependent Down-Modulation of the Colony-Stimulating Factor-1 Receptor upon Activation with Interferon-?/Lipopolysaccharide.- The Interleukin-2 Receptor (CD25 and p75) in Human Monocytes and Macrophages.- Combinations of Cytokines and Cytotoxic Drugs In Vitro.- Synergism of Hematopoietic Cytokines and Cytosine Arabinoside in the Treatment of Acute Myelogenous Leukemia: Experimental Rationales.- Effects of Recombinant Human Cytokines on Cytarabine Activity in K562 Human Myeloid Leukemia Cells.- Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Increases DNA Polymerase Activity in Acute Myeloid Leukemia Blasts In Vitro and In Vivo.- Kinetic and Genetic Resistance in Acute Leukemia.- Combination of Hematopoietic Growth Factors Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-1 Reduces Toxicity of Cisplatin, Carboplatin, and Azidothymidine on Normal Human and Murine Hematopoietic Progenitors.- The Susceptibility of Human Leukemia Cells to Allogeneic and Autologous Lymphokine-Activated Killer Cells and Augmentation of the Susceptibility by Exposure of Target Cells to Cytotoxic Drugs In Vitro and In Vivo.- Other Effects and Factors.- CD16 Stimulation Induces Stronger Accumulation of Cytokine mRNA in Natural Killer Cells than in Non-MHC-Restricted T Lymphocytes.- Influence of Chemo- and Radiotherapy on Interleukin-1 Production by Mononuclear Cells of Children with Hematological Malignancies.- Pokeweed Mitogen Induction of Interleukin-2 and Interleukin-6 in Mononuclear Cells: An Alternative Approach to the Combined Phytohemagglutinin/Phorbol Myristrate Acetate Stimulation In Vitro.- Immunomodulatory Activity of Hexadecylphosphocholine: Hexadecylphosphochloine-Meidated Enhancement of T-Cell Response.- Long-Term Culture and Expansion of Adherent Lymphokine-Activated Killer Cells.- Bomirski Ab Melanoma as a Model of Tumor-Induced Cachexia.- Preclinical Evaluation of Cytokines in Animal Models.- In Vivo Effects of Interleukin-6 and Leukemia Inhibitory Factor on Thrombopoiesis in Primates.- In Vivo Synergism of Interleukin-3 and Interleukin-6 on Thrombopoiesis in Primates.- Clinical Data.- Cytokines and Their Soluble Receptors in the Serum.- Increased Erythropoietin Response After Treatment with Cisplatin, Etoposid, and Bleomycin in Patients with Testicular Cancer.- Systemic Release of Tumor Necrosis Factor Alpha in Human Allogeneic Bone Marrow Transplantation: Clinical Risk Factors, Prognostic Significance, and Therapeutic Approaches.- Sequential Release of Tumor Necrosis Factor Alpha and Tumor Necrosis Factor Receptors in Complications of Human Bone Marrow Transplantation.- Tumor Necrosis Factor ? in the Course of Allogeneic and Autologous Bone Marrow Transplantation.- Differences in Stimulated Cytokine Release Between Sleep and Sleep Deprivation.- Interleukin-5 Expressing Allergen-Specific T Cells in Patients with House Dust Mite Sensitization: Analysis at a Clonal Level.- G-CSF.- Issues in the Clinical Development of Recombinant Methionyl Human Granulocyte Colony-Stimulating Factor: A Review.- The Use of Recombinant Methionyl Human Granulocyte Colony-Stimulating Factor Following High-Dose Chemotherapy and Autologous Bone Marrow Transplantation.- Recombinant Methionyl Human Granulocyte Colony-Stimulating Factor in High-Risk Non-Hodgkin’s Lymphoma Treated with VIM and CHOP: Preliminary Results of a Phase I/II Study.- Granulocyte Colony-Stimulating Factor in the Therapy of Myeloid Leukemia.- Granulocyte Colony-Stimulating Factor Corrects Neutropenia and Associated Clinical Symptoms in Children with Severe Congenital Neutropenia.- Severe Reversible Renal Failure Induced by Recombinant Human Granulocyte Colony-Stimulating Factor in a Child with Chronic Acquired Agranulocytosis.- In Vitro Functions of Granulocyte Colony-Stimulating Factor Induced Neutrophils.- Impaired Calcium Mobilization and Abnormalities in Microfilamentous Cytoskeletal Organization in Granulocyte Colony-Stimulating Factor Induced Neutrophils from Patients with Severe Congenital Neutropenia.- GM-CSF.- Treatment of Poor-Risk Neuroblastoma with Intensive Chemotherapy and Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor.- Treatment of Relapsed Acute Myeloid Leukemia with Granulocyte-Macrophage Colony-Stimulating Factor and Intensive Chemotherapy.- Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor in Aplastic Anemia: A Phase I/II Trial Emphasis on Very Severe Neutropenia and Active Infection.- Successful Third Bone Marrow Transplantation for Severe Aplastic Anémia: Possible In Vivo Synergism of Granulocyte-Macrophage Colony-Stimulating Factor and Erythropoietin.- Stimulation of Peripheral Blood Progenitor Cells by Chemotherapy and Granulocyte-Macrophage Colony-Stimulating Factor in Lymphoproliferative Diseases.- Autologous Transplantation of Blood Stem Cells Mobilized with Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Subsequent to Chemotherapy for Relapsed Hodgkin’s Disease.- Immunological Characterization of Blood Stem Cell Autografts Collected Under Administration of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor.- Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Serum Levels of Soluble CD25, CD8, an CD4 in Patients with Hodgkin’s Disease in Sensitive Relapse.- Migration of Neutrophils to the Oral Mucosa During Treatment with Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor.- Interleukin-1.- Clinical Trials of Interleukin-1?.- Interleukin-3.- Clinical Evaluation of Interleukin-3.- Response to Interleukin-3 Treatment in Graft Failure After Bone Marrow Transplantation.- Erythropoietin.- Erythropietin Treatment in Allogeneic Bone Marrow Transplantation: A Prospective and Randomized Trial.- In Vivo Effects of Recombinant Human Erythropoietin on Circulating CD34+ Cells of Uremic Patients.- Interferons.- Interferon-?-2b in the Treatment of Chronic Myeloid Leukemia.- Interferon-?-2a in the Treatment of Chronic Myeloid Leukemia: Results of the Spanish Group on Interferon-?-2a in CML.- Complex Karyotype Evolution Influenced by Interferon Therapy in a Case of Ph-Positive Chronic Myeloid Leukemia.- Treatment of Primary and Relapsed Angioimmunoblastic-Type T-Cell Lymphoma with Recombinant Human Interferon-?.- New Aspects in the Treatment of Human Immunodeficiency Virus Related Koposi’s Sarcoma with High-Dose Intralesional Recombinant Interferon ? 2b.- Combination of Interferon-? and Standard Chemotherapy in Advanced Malignancies.- A 21-kDa Protein as Marker in the Course of Chemotherapy Combined with Cytokines: Interferon-? or Granulocyte-Macrophase Colony-Stimulating Factor.- Treatment with Human Recombinant Tumor Necrosis Factor-? of Patients with Acute Myeloid Leukemia and Chronic Myeloid Leukemia in its Accelerated or Blastic Phase.- Outpatient Therapy of Advanced Malignancies Using Recombinant Interleukin-2 and Recombinant Inteferon-? With or Without Chemotherapy.- Treatment of Metastatic Melanoma with Interferon-? and Interleukin-2: Significant Improvement with a New-Dosing Schedule.- Sequential Chemoimmunotherapy in the Treatment of Metastatic Melanoma.- Interleukin-2 in Combination with Dacarbazine in the Treatment for Malignant Melanoma.- Characterization of CD3+ and CD56+ Lymphocyte Subsets in Melanoma Patients After In Vivo Recombinant Interleukin-2 Administration.- Low-Dose Subcutaneous Interleukin-2 in Human Multiple Myeloma: Current Results of a Phase I/II Pilot Study.- Tolerance and Biological Activity of Bolus Administration of Increasing Doses of Glycosylated Recombinant Interleukin-2 (SR 29009) in Patients with Hematological Malignancy.- Treatment of Relapsed Acute Leukemias with Systemic Recombinant Interleukin-2 (RU 49637).- Use of Recombinant Interleukin-2 (RU 49637) After Autologous Bone Marrow Transplantation in Patients with Hematological Disease: Phase I–II Study.- Phase I/II Trial with Low-Dose Interleukin-2 and Interferon-Gamma in Children with High-Risk Leukemia and Non-Hodgkin’s Lymphoma After Autologous Bone Marrow Transplantation.- Autologous Bone Marrow Transplantation with 10-Day-Cultured Bone Marrow Activated by Interleukin-2 in Two Patients with Acute Lymphoblastic Leukemia.- Antibody Formation in Cancer Patients Treated with Recombinant Interleukin-2 Alone or in Combination with Interferon-? 2b.