Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases

ISBN-13: 9783642421822 / Angielski / Miękka / 2014 / 209 str.

R. Numerof; Charles A. Dinarello; Khusru Asadullah

Opis

Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56^th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases."

Spis treści

Inhibition of IFN-? as a Method of Treatment of Various Autoimmune Diseases, Including Skin Diseases.- Cytokine Targeting in Psoriasis and Psoriatic Arthritis: Beyond TNF?.- Inhibitors of Histone Deacetylases as Anti-inflammatory Drugs.- Dendritic Cell Interactions and Cytokine Production.- Lysosomal Cysteine Proteases and Antigen Presentation.- DCs and Cytokines Cooperate for the Induction of Tregs.- Induction of Immunity and Inflammation by Interleukin-12 Family Members.- The Role of TNF? and IL-17 in the Development of Excess IL-1 Signaling-Induced Inflammatory Diseases in IL-1 Receptor Antagonist-Deficient Mice.- TGF?-Mediated Immunoregulation.- TNF Blockade: An Inflammatory Issue.- IL-1 Family Members in Inflammatory Skin Disease.- Regulatory T Cells in Psoriasis.