Cytokine Knockouts

ISBN-13: 9781617374159 / Angielski / Miękka / 2010 / 471 str.

Giamila Fantuzzi

Opis

Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.

Recenzje

Foreword by Scott K. Durum
Reviews of the first edition:
...should be the most useful for everybody who wants to learn about those thrilling, novel leads into the biology of the immune system and the pathogenesis of human diseases. -from the Foreword by Klaus Rajewsky, Institute of Genetics, Cologne
". . .a very nice compendium of research in a very important area . . . should be on the shelves of all life science and biomedical libraries."-5 Stars, Doody's Health Sciences Book Review Journal

"...essential reading for...laboratory scientists, including immunologists, developmental and cell biologists, and experimental pathologists..."
-Modern Pathology

"...a very nice compendium of research in a very important area...should be on the shelves of all life science/biomedical libraries."
-Doody's Health Sciences Book Review Journal

"This remarkable book is a powerful source of information and ideas."
-Annales de Biologie Clinique

Spis treści

Part I. Cytokine Knockouts in Models of Human Disease Cytokine Knockouts in Inflammation Pietro Ghezzi The Use of Cytokine Knockouts to Study Host Defense Against Infection Charles A. Dinarello The Use of Cytokine Knockouts in Animal Models of Autoimmune Disease Alfons Billiau, Hubertine Heremans, and Patrick Matthys The Use of Cytokine Knockout Mice in Cancer Research Robert H. Wiltrout, Jon M. Wigginton, and William J. Murphy The Use of Cytokine Knockout Mice in Neuroimmunology Giamal N. Luheshi, Emmanuel Pinteaux, and Hervé Boutin Part II. Cytokine Knockout Mice The Role of IL-1 in the Immune System Susumu Nakae, Reiko Horai, Yutaka Komiyama, Aya Nambu, Masahide Asano, Akio Nakane, and Yoichiro Iwakura IL-1 Receptor Antagonist-Deficient Mice Martin J. H. Nicklin and Joanna Shepherd A Unique Role for IL-2 in Self-Tolerance Thomas Hünig and Anneliese Schimpl Molecular Basis for Binding Multiple Cytokines by gc: Implications for X-SCID and Impaired gc-Dependent Cytokine Receptor Function Ferenc Olosz and Thomas R. Malek G-CSF, GM-CSF, and IL-3 Knockout Mice Thomas Enzler and Glenn Dranoff IL-4 Knockout Mice Pascale Kropf and Ingrid Müller Role of IL-5 in Immune and Pathological Responses in the Mouse Paul S. Foster and Simon P. Hogan. IL-6 Knockout Mice, Valeria Poli and Diego Maritano IL-10 and IL-2 Knockout Mice: Effect on Intestinal Inflammation Karen L. Madsen and Humberto Jijon IL-12-Deficient Mice Luciano Adorini IL-13 and Double IL-4/IL-13 Knockout Mice Duncan R. Hewett and Andrew N. J. McKenzie IL-15: Insights from Characterizing IL-15-Deficient Mice Pallavur V. Sivakumar, Sandra N. Brown, Ananda W. Goldrath, Anne Renee Van der Vuurst de Vries, Joanne L. Viney, and Mary K.Kennedy IL-18 and IL-18 Receptor Knockout Mice Hiroko Tsutsui, Tomohiro Yoshimoto, Haruki Okamura, Shizuo Akira, and Kenji Nakanishi Mice Knockouts for Chemokines and Chemokine Receptors Jane M. Schuh, Steven L. Kunkel, and Cory M. Hogaboam IFN-g and IFN-g Receptor Knockout Mice, Dyana Dalton Macrophage Migration Inhibitory Factor (MIF)-Deficient Mice Gunter Fingerle-Rowson, Abhay R. Satoskar, Richard Bucala Osteopontin, a Surprisingly Flexible Cytokine: Functions Revealed from Osteopontin Knockout Mice Susan R. Rittling, Anthony W. O'Regan, and Jeffrey S. Berman RANKL, RANK, and OPG Young-Yun Kong and Josef M. Penninger Targeting the TGF-b Pathway In Vivo: Defining Complex Roles for TGF-b Signaling in Immune Function, Wound Healing, and Carcinogenesis Lawrence Wolfraim, Mizuko Mamura, Anita Roberts, and John J. Letterio Physiologic Roles of Members of the TNF and TNF Receptor Families as Revealed by Knockout Models Sergei A. Nedospasov, Sergei I. Grivennikov, and Dmitry V. Kuprash Index

Blurb

Carrying on the high standards of the much-praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous, often surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology. For those not familiar with cytokine research, in part I the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research. In their discussion of research methodology and data interpretation, the writers stress the need for caution when trying to interpret data, especially when these may affect clinical practice, and the danger of forgetting the possible effects of redundancy and of unspecified perturbations in the immune system when a single gene is deleted. Chapters dealing with mice deficient for single cytokines and/or cytokine receptors are presented in part II.
Cutting-edge and highly instructive, Cytokine Knockouts, Second Edition illuminates for researchers today both the usefulness of cytokine knockout mice to study a wide variety of cytokine phenomena and the possible complications of such studies.