Cytogenetics: Basic and Applied Aspects

ISBN-13: 9783642728044 / Angielski / Miękka / 2014 / 401 str.

Gunter Obe; Armin Basler

Opis

Different aspects of cytogenetics, such as the molecular structure of eukaryotic chromosomes, computerized analyses of chromosomes, evolution of karyotypes, chromosomes and cancer, chromosomes in genetic toxicology, and chromosomal aberrations (- induction, - in human populations, - in human eggs and sperm) are comprehensively covered in this book. New techniques and approaches accompany overviews of all the different aspects of eukaryotic chromosomes. Especially the combination of recent research data with the application of their results in modern medicine makes the book invaluable to researchers as well as to clinicians.

Spis treści

1. Towards Understanding the Structure of Eukaryotic Chromosomes.- 2. The Magic of Cytogenetic Technology.- 3. Automated Cytogenetics with Modern Computerized Scanning Microscope Photometer Systems.- 4. The Chromosomes of Man: Evolutionary Considerations.- 5. Chromosome Evolution of Cervidae: Karyotypic and Molecular Aspects.- 6. Cytogenetic Studies in Human Neoplasia.- 7. Surveillance of Germinal Human Mutations for Effects of Putative Environmental Mutagens and Utilization of a Chromosome Registry in Following Rates of Cytogenetic Disorders.- 8. Cytogenetic Study of the Offspring of Atomic Bomb Survivors, Hiroshima and Nagasaki.- 9. Chromosome Studies of Human in Vitro Fertilization (IVF) Failures.- 10. Chromosome Analyses Using Human Spermatozoa.- 11. Class II Restriction Endonucleases.- 12. Analysis of the Eukaryotic Chromosome Organization with Restriction Endonucleases.- 13. Chromosome Aberrations Induced by Restriction Endonucleases.- 14. DNase I, Chromosome Aberrations, and Cancer.- 15. DNA Damage and Cytogenetic End Points.- 16. Sister Chromatid Exchanges.- 17. Cytogenetic Surveillance of Occupational Exposures.- 18. Clastogenicity of Methylated p-Benzoquinones: Chemical Warfare in Nature?.- 19. Scientific Justification of Testing Chromosome Mutations and Regulatory Requirements for the Assessment of Mutagenicity.