Cushing's Syndrome: Pathophysiology, Diagnosis and Treatment

ISBN-13: 9781617797095 / Angielski / Miękka / 2012 / 304 str.

Marcello D. Bronstein

Opis

This book examines the current state of understanding of Cushing's Syndrome, including its causes, controversies in diagnosis, related conditions associated with obesity, factors complicating diagnosis and a variety of approaches to treatment.

Recenzje

From the reviews:

"This book contains 23 chapters written by 56 carefully selected experts from three continents. There are special chapters on physiology and pathophysiology of hypothalamic-pituitary-adrenal system as well as on the etiology of Cushing's syndrome. ... Several chapters deal in detail with surgical management, adrenal directed treatment, radiation therapy and medical management. ... this book gives outstanding knowledge and is enriching the contemporaneous status of art on Cushing's syndrome." (Endocrine Regulations, January, 2012)

"Part of the Contemporary Endocrinology series, a very comprehensive treatise on this difficult to diagnose and treat to disease. Written by multidisciplinary scientists from several countries, it reviews in 23 chapters the physiology and pathophysiology of the HPA axis, the etiology and clinical features of Cushing's syndrome (CS), diagnostic methods and problems, the various methods of treatment and differential diagnosis including ACTH independent CS. ... Clearly written and highly illustrated ... . Recommended." (Pediatric Endocrinology Reviews (PER), Vol. 9 (2), December, 2011)

Spis treści

Chapter 1: Physiology and Pathophysiology of the HPA axis, by Margareth Castro and Ayrton Custodio Moreira Chapter 2: Etiologies of Cushing´s syndrome, by John Newell-Price Chapter 3: Pathogenesis of corticotropic tumors, by Shlomo Melmed Chapter 4: Pathogenesis of adrenocortical tumors, by Madson Q. Almeida, Emilia M. Pinto, and Ana Claudia Latronico Chapter 5: Clinical features of Cushing´s syndrome, by Oscar Bruno Chapter 6: Laboratorial diagnosis of Cushing´s Syndrome: Differential diagnosis with pseudo-Cushing´s conditions as obesity, alcoholism and depression, by Francesco Cavagnini Chapter 7: Laboratorial diagnosis of Cushing´s syndrome: Differential diagnosis among the different causes of ACTH-dependent and ACTH-independent Cushing´s syndrome, by Antonio M. Lerário and Marcello D.Bronstein Chapter 8: Imaging for the differential diagnosis of Cushing´s syndrome: MRI, CT and isotopic scanning, by Wouter de Herder Chapter 9: Inferior petrosal sampling for the differential diagnosis of ACTH dependent Cushing´s syndrome, by James W. Findling and Bradley Javorsky Chapter 10: ACTH-dependent Cushing syndrome: Treatment of Cushing´s disease A) Treatment of Cushings Syndrome: Surgical Treatment, by Edward Laws B) Adrenal-Directed Treatment Options for Cushing’s Disease, by William Young C) Radiation Therapy and Stereotactic Radiosurgery for Cushing’s Disease, by Jason P Sheehan D) Medical Management of Cushing’s syndrome, by Peter Trainer Chapter 11: ACTH-dependent Cushing syndrome: Clinical and diagnostic aspects, and treatment approaches for ectopic Cushing´s syndrome, by Ashley Grossman Chapter 12: Revisiting the Nelson’s syndrome: Corticotroph Tumor Progression after bilateral adrenalectomy in Cushing’s disease, by Xavier Bertagna Chapter 13: ACTH-independent Cushing´s syndrome: Adrenocortical tumors, by Maria Candida Fragoso, Ana Claudia Latronico and Berenice B. Mendonca Chapter 14: ACTH-independent Cushing´s syndrome: Bilateral macronodular hyperplasia, by Andre Lacroix Chapter 15: ACTH-independent Cushing´s syndrome: primary pigmented nodular adrenal disease in the context of Carney´s complex, by Constantine A Stratakis Chapter 16: Glucocorticoid Resistance, by Elisabeth F.C. van Rossum and Steven W. Lamberts Chapter 17: Post-operative replacement and assessment of HPA axis recovery in Cushing’s syndrome, by John Wass Chapter 18: Special aspects of Cushing´s syndrome: Pregnancy, by David Aron Chapter 19: Special aspects of Cushing´s syndrome: Childhood, by M. O. Savage Chapter 20: Special aspects of Cushing´s syndrome: Cyclic Cushing´s syndrome, by Franco Mantero

Blurb

Cushing´s syndrome is a relatively rare clinical disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function and growth impairment in children, all of which severely reduce quality of life and life expectancy. Cushing’s Syndrome: Pathophysiology, Diagnosis and Treatment reviews the difficulties in distinguishing Cushing’s syndrome from these and other common conditions, such as central obesity, menstrual irregularity and depression. It also provides state-of-the-art information on various strategies to establish the diagnosis of Cushing’s syndrome and the differential diagnosis among its diverse etiologies, as well as therapeutic approaches. Additionally, a range of conditions that represent challenges for the diagnosis and treatment--such as renal failure, pediatric age, cyclic hypercortisolism, and pregnancy--are covered in detail. A valuable resource not only for endocrinologists but also internal medicine physicians, gynecologists, pediatricians, , pituitary surgeons and urologists, Cushing’s Syndrome: Pathophysiology, Diagnosis and Treatment provides insights by experts that will help all physicians dealing with Cushing´s syndrome to expand their knowledge about the condition and provide targeted, comprehensive care.