Current Trends in Histocompatibility: Volume 1 Immunogenetic and Molecular Profiles

ISBN-13: 9781468437607 / Angielski / Miękka / 2012 / 543 str.

Ralph Reisfeld

Opis

Information about histocompatibility antigens is expanding so rapidly that it is difficult to remain abreast of aB advances. In these volumes, we have made an effort to bring together the most current work on topics that have generated most of the re cent advances and discussions. We have asked each author to present and interpret his most current work, and we have judiciously refrained from imposing our own prejudices and viewpoints. Although there is obvious overlap in some individual topics, we have encouraged this to provide the reader with as many different and some- times opposing viewpoints as possible. This approach will, we liope, give a broad overview of current ideas in the field. We wish to thank all contributors for their timely and exciting manu- scripts, and we sincerely hope that the reader will benefit from these volumes. R. A. Reisfeld S. Ferrone La Jolla ix Contents I. Serology and Genetics Chapter 1 Studies of HLA-DR Antigens by Complement Fixation Jacques M. Colombani, Laurent Degos, Virginia Lepage, Helene Dastot, Muriel Reboul, and Pierre Lethielleux 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. Material and Methods. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3. Results and Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3. 1. Screening for Anti-HLA-DR Complement-Fixing Sera . . . . . . . . 4 3. 2. Expression of HLA-A, -B and -DR Antigens on Peripheral Blood Lymphocytes during Phytohemagglutinin Stimulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3. 3. Expression of HLA-A, -B and -DR Antigens on Peripheral Blood Lymphocytes during Concanavalin A Stimulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 4.

Spis treści

I. Serology and Genetics.- 1 Studies of HLA-DR Antigens by Complement Fixation.- 2 Serological and Cellular Recognition of Human Histocompatibility Antigens.- 3 Are D and DR Two Distinct Entities?.- 4 Genetic Organization, Tissue Expression, and Functional Role of Murine Ia Antigens.- 5 Expression of Syngeneic and Allogeneic H-2 Antigens on Tumor Cells.- 6 Hybrid Sterility Gene Located in the T/t-H-2 Supergene on Chromosome 17.- 7 Interspecies MHS Relationships Studied by Serological and Cellular Cross-Reactions.- 8 The DR Region of HLA: Serological Analysis.- 9 The Genetics of B-Cell Alloantigens.- 10 Serological Testing of the HLA Antigens: Problems and Approaches to Standardization.- 11 Carbohydrate-Defined Antigens Controlled by the I Region.- 12 Antigenic Products of the HLA-D Region.- 13 The Polymorphism of I-Region-Encoded Antigens among Wild Mice.- 14 HLA Polyclonal and Monoclonal Xenoantibodies: Production, Characterization, and Application to the Study of HLA Antigens.- II. Chemistry.- 15 Structural Studies of the Murine Ia Alloantigens.- 16 Ia Antigens: Molecular Components in Immune Regulation?.- 17 Structure of H-2 Major Histocompatibility Complex Products: Recent Studies on the H-2Kb Glycoprotein and on the H-2Kb MHC Mutants.- 18 Are the Classic Transplantation Antigens Primitive Cell-Surface Antibodies?.- 19 Functional Implications of the Structural Diversity of Murine Ia and Human DR Antigens.- 20 Complete Primary Structure of Human Histocompatibility Antigen HLA-B7: Its Evolutionary and Functional Implications.- 21 Antigenic Structures of HLA(A,B,C) Antigens: Chymotryptic Glycopeptides Carrying HLA(A,B,C) Determinants.- 22 Structural Analysis of HLA-DR Antigens.