Current Topics in Innate Immunity II

ISBN-13: 9781461401056 / Angielski / Twarda / 2011 / 354 str.

John D. Lambris; George Hajishengallis

Opis

Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This Volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece. It includes topics related to the biology and function of Toll-like and other pattern-recognition receptors, complement and its crosstalk with other physiological systems, inflammatory mechanisms and diseases, natural killer cells, and the cooperative interplay between innate and adaptive immune cells. This book is an excellent source of information for researchers and clinicians with interests in immunology, host- microbe interactions, and infectious and inflammatory diseases.

Spis treści

Pentraxins in humoral innate immunity.- galectins as pattern recognition receptors: structure, function, and evolution.- the role of innate immunity in trafficking of hematopoietic stem cells – an emerging link between activation of complement cascade and chemotactic gradients of bioactive sphingolipids.- interaction of the microbiome with the innate immune response in chronic wounds.- keystone species and community service through manipulation of innate immunity.- a conserved host and pathogen site on immunoglobulins: structural and functional aspects.- advances in understanding the structure, function, and mechanism of the scin and efb families of staphylococcal immune evasion proteins.- granzyme b: a new crossroad of complement and apoptosis.- role of c3, c5 and anaphylatoxin receptors in acute lung injury and in sepsis.- complement mediated ocular angiogenesis.- platelets, complement, and contact activation: partners in inflammation and thrombosis.- nuclear factor-κb in immunity and inflammation: the treg and th17 connection.- function of act1 in il-17 family signaling and autoimmunity.- differential effect of inhibiting md-2 and cd14 on lps- versus whole e. coli bacteria-induced cytokine responses in human blood.- zebrafish: model for the study of inflammation and the innate immune response to infectious diseases.- monocyte-derived inflammatory dendritic cells in the granuloma during mycobacterial infection.- nk/dc crosstalk in anti-viral response.- innate-adaptive crosstalk: how dendritic cells shape immune responses in the cns.- nutritional immunity: homology modeling of nramp metal import.