Current Thoughts on Dementia: From Risk Factors to Therapeutic Interventions

ISBN-13: 9789811676055 / Angielski / Twarda / 2022

Ashraf, Ghulam MD

Opis

This informative book discusses the latest research on the risk factors and therapeutics in dementia. WHO calls dementia a public health priority. Dementia manifests as a group of symptoms associated with decline in memory or other thinking skills and is severe enough to reduce a person's ability to perform everyday activities. It occurs frequently among elderly people, but it is not necessarily part of the normal aging process. The book has been divided into two broad sections. The first section reviews the risk factors involved in developing dementia, including various medical conditions, lifestyle choices, as well as genetics. The latter section describes various therapeutic interventions in dementia. Although there is no known cure for dementia, this book underlines the current treatment strategies that could momentarily reduce the symptoms and improve the quality of life of the patients. This book highlights the global effort to find better ways to halt the progression of dementia and develop novel therapeutic strategies.  The book would be an interesting read for advanced graduate students and researchers working in the field of neuroscience, genetics, and medicine. It will generate good interest to neurologists, psychiatrists, geriatricians, cardiologists, internal medicine practitioners, epidemiologist, and public health workers.

Spis treści

Risk Factors

§  Apolipoprotein E (APOE)

§  Histone modifications, demethylation, and microRNA regulation

§  Triggering receptor expressed on myeloid cells 2 (TREM2)

§  Brain-derived neurotrophic factor (BDNF)

§  Bridging integrator 1 (BIN1)

§  Protein tyrosine phosphatase 1B (PTP1B)

§  Leptin signaling

§  Insulin signaling

§  Autophagic  dysfunction

§  Ubiquitin-proteasome system dysfunction

§  Circadian dysfunction

§  Endoplasmic Reticulum Stress

§  Depression

§  Normal pressure hydrocephalus

§  Antiphospholipid antibodies

§  Sex hormones

§  Changes in blood factors

§  Infection-induced systemic inflammation

§  Microbiota

§  Abdominal visceral fat

§  Atypical microvascular morphology

§  Plasma exosomes spread

§  Changes in visual cortex

§  Obesity, dyslipidemia, hyperglycemia and hypertension

§  Environmental pollutions

 

Therapeutic Interventions

§  NMDA receptor antagonists 

§  Calcium channel blockers

§  Catecholamine

§  Statins

§  Immunotherapy

§  Quitting smoking

§  Physical activity

§  Diet and nutrition

§  Natural products as promising drug candidates

§  Nanotechnological applications

§  Electroacupuncture

§  Repetitive transcranial magnetic stimulation

§  Transcranial direct current stimulation

§  Reminiscence therapy

§  Reality orientation therapy

§  Bright-light therapy

§  Snoezelen multi-sensory stimulation

§  Behavioral therapy

§  Brain-computer interface applications

§  Music therapy

§  Hypoxic-hyperoxic training

§  Cognitive rehabilitation

§  Cognitive creativity

§  Stem cell research

O autorze

Ghulam Md Ashraf is currently working as an Associate Professor at King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. He has received his PhD in Biochemistry from Aligarh Muslim University, India in 2010. Dr. Ashraf has to his credit 273 publications ranging from peer-reviewed journal articles, books, and book chapters published with scholarly publishers (total citations: 4618, h-index: 33, i10-index: 128). He has been involved in 19 research projects funded by various agencies of Saudi Arabia, and is associated with renowned professional societies like Royal Society of Medicine (Fellow), Royal Society of Biology (Member) and American Society for Biochemistry and Molecular Biology (Member). Dr. Ashraf’s current research work focuses on investigating the role of anti-diabetic drugs in pyschotic and dementia conditions. Dr. Ashraf is also involved in editorial capacity with many reputed journals like PLOS one, Scientific Reports, Current Neuropharmacology, Frontiers in Bioscience-Landmark, Neural Regeneration Research, Current Proteins and Peptides, Journal of Proteomics, to mention a few.

Md. Sahab Uddin is a Registered Pharmacist and a Research Scholar in the Department of Pharmacy at Southeast University, Dhaka, Bangladesh. Md. Uddin’s research interest is how neuronal operation can be restored to abate Alzheimer’s dementia. He has published copious articles in peer-reviewed international scientific journals. Md. Uddin has been enlisted in the Stanford University Lists of World's Top 2% Influencing Researchers based on the citation impact from Scopus of the single calendar year 2019. He has also authored and edited several books related to neuropharmacology and neurodegenerative disorders. Md. Uddin also serves as a guest editor, editorial, and reviewer board member of numerous scholarly journals. He is an active ad-hoc reviewer for more than 50 journals and reviewed more than 200 papers. Md. Uddin is a member of many national and international professional bodies. Moreover, he is the Founder and Executive Director of the Pharmakon Neuroscience Research Network, an open innovation hub bringing together neuroscientists to advance brain health. He received his BPharm in 2014, securing a first position from the Department of Pharmacy, Southeast University, Bangladesh.