Crispr: Biology and Applications

ISBN-13: 9781683670377 / Angielski / Twarda / 2022 / 230 str.

Rodolphe Barrangou; Erik Sontheimer; Luciano Marraffini

Spis treści

Contributors ViiPreface xiS E C T I O N IDiversity of CRISPR-Cas Systems 11 CRISPR-Cas Systems: Core Features and Common Mechanisms 3Rodolphe Barrangou, Luciano A. Marraffini, and Erik J. Sontheimer2 Evolutionary Classification of CRISPR-Cas Systems 13Kira S. Makarova, Yuri I. Wolf, and Eugene V. Koonin3 Molecular Mechanisms of Type I CRISPR-Cas Systems 39John van der Oost4 Molecular Mechanisms of Type II CRISPR-Cas Systems 53Tautvydas Karvelis and Virginijus Siksnys5 Mechanism of Type III CRISPR-Cas Immunity 71Luciano A. Marraffini6 Type V CRISPR-Cas Systems 85Morgan Quinn Beckett, Anita Ramachandran, and Scott Bailey7 CRISPR-Cas13: Biology, Mechanism, and Applications of RNA-Guided, RNA-Targeting CRISPR Systems 99Omar O. Abudayyeh and Jonathan S. GootenbergS E C T I O N IICRISPR-Cas Biology 121 8 CRISPR-Cas, Horizontal Gene Transfer, and the Flexible (Pan) Genome 123Uri Gophna9 Evasion Tactics Manifested by Bacteriophages against Bacterial Immunity 131Jenny Y. Zhang, Sutharsan Govindarajan, and Joseph Bondy-Denomy10 Regulation of CRISPR-Cas Expression and Function 145Leah M. Smith, Aroa Rey Campa, and Peter C. FineranS E C T I O N IIICRISPR-Based Technologies and Applications 16311 Genome Editing with CRISPR-Cas Systems 165Peter Lotfy and Patrick D. Hsu12 Genetic and Epigenetic Modulation of Gene Expression by CRISPR-dCas Systems 195Jasprina N. Noordermeer, Crystal Chen, and Lei S. Qi13 CRISPR Screens 213Jonathan D. D'Gama, Joseph S. Park, and Matthew K. Waldor14 CRISPR-Based Antimicrobials 233Justen Russell and David Bikard15 Exploiting CRISPR-Cas Systems To Provide Phage Resistance in Industrial Bacteria 249Rodolphe Barrangou and Avery Roberts16 Recording Biological Information with CRISPR-Cas Systems 267Mariia Y. Cherepkova, Tanmay Tanna, and Randall J. PlattAfterword 281Index 283

O autorze

ABOUT THE EDITORSRodolphe Barrangou is the Todd R. Klaenhammer Distinguished Professor in the Department of Food, Bioprocessing and Nutrition Sciences at North Carolina State University; a member of the AAM, NAS, NAE, and NAI; a cofounder of Intellia Therapeutics, Locus Biosciences, Ancilia Biosciences, CRISPR Biotechnologies, and TreeCo; and Editor- in-Chief of The CRISPR Journal.Erik J. Sontheimer is the Pillar Chair in Biomedical Research and Professor in the RNA Therapeutics Institute at the University of Massachusetts Chan Medical School; an Associate Editor of RNA; a member of the AAM; a cofounder of Intellia Therapeutics; and a Scientific Advisory Board member at Tessera Therapeutics.Luciano A. Marraffini is the Kayden Family Professor and Head of the Laboratory of Bacteriology at The Rockefeller University; a Howard Hughes Medical Institute Investigator; a member of the AAM, AAAS, and NAS; and a cofounder of Intellia Therapeutics, CRISPR Biotechnologies, and Eligo Biosciences.