Coumarins: Biology, Applications and Mode of Action

ISBN-13: 9780471969976 / Angielski / Twarda / 1997 / 360 str.

Richard O'Kennedy; R. O'Kennedy; R. D. Thornes

Opis

The greatest need in clinical medicine today is for the long term control of cellular immunity. Coumarin, a simple molecule, and most of its derivatives, have been known for more than a century but their vital role in plant and animal biology has not been fully exploited. Coumarin prevents disease, modulates growth and maturation and defence systems and may have anti-oxidant properties. This volume presents a summary of the use of coumarins over a wide range of applications.

Spis treści

List of contributors.

Preface.

History of the Development and Applications of Coumarin and Coumarin–related Compounds (I. Weinmann).

The Chemistry and Occurrence of Coumarins (G. Keating & R. O′Kennedy).

The Metabolism of Coumarin (O. Pelkonen).

The Effects of Coumarin and its Metabolites on Cell Growth and Development (B. Seliger).

Coumarin as an Immunomodulator (G. Zlabinger).

The mode of Entry of Coumarin into Cells and its Effects on Cell–Cell Communication and Migration (K. S. Zlabinger).

Coumarin in the Treatment af Lymphoedema and Other High–Protein Oedemas (J. R. Casley–Smith, J. R.Casley–Smith).

Mode of Action of Coumarin in the Treatment of Thermal Injuries (N. Piller).

Renal Cell Carcinoma: The Background, Rationale and Current Development of Coumarin (1,2–benzopyrone) as a Potential Therapeutic Agents (S. W. Ebbinghaus, et al.).

The Potential Role of Coumarins in the Therapy of Prostate Cancer (J. Mohler, et al.).

Clinical and Biological Observations Associated with Coumarins (R. Thornes).

Analysis of Coumarins (D. Bogan, et al.).

Coumarins – Multifaceted Molecules with Many analytical and Other Applications (D. Cooke et al.).

Suggested Modes of Action of Coumarins and Some Comments on their Significance (R. O′Kennedy & R. Thornes).

Index.

Blurb

Coumarins are a group of compounds that have important roles as food constituents; as anti–oxidants, stabilisers, and immunomodulatory substances; as fluorescent markers for use in analysis, in lasers and in clinical use. Coumarins: Biology, Applications and Mode of Action predominantly focuses on the parent compound, coumarin, and its main metabolite in humans, 7–hydroxycoumarin. It describes in detail every facet of these compounds including history, toxicology, chemistry, metabolism, analysis, clinical, veterinary and other applications, their roles as immunomodulatory agents and speculates on their mode of action. Features include:
∗ New insights into mode of action of coumarins
∗ Comprehensive summary of new coumarin compounds
∗ Detailed accounts of methods used for analysis
∗ Applications of coumarins for diverse methods of analysis
This volume will be of interest to those working in biochemistry, chemistry, pharmacology, clinical sciences and toxicology.