Controlled Drug Delivery of Hydrophobic Drug

ISBN-13: 9786202518062 / Angielski / Miękka / 2020 / 96 str.

Rajesh Jagtap; Sneha Jagtap; Sandeep Chavan

Opis

Glipizide, an oral hypoglycemic agent, is one of the most commonly prescribed drugs for the treatment of patients with type II diabetes mellitus. It is practically water-insoluble, thus it belongs to class-II of Biopharmaceutical Classification System (BCS). Glipizide has a relatively short elimination half-life (2-4 h), thereby requiring twice daily dosing in large number of patients, which often leads to non-compliance. Thus, there is a strong clinical need and market potential for a dosage form that will deliver glipizide in a controlled manner to a patient needing this therapy, thereby resulting in a better patient compliance. The aim of present investigation was to enhance the solubility by using beta-cyclodextrin binary complexation and impart a controlled release in a single formulation in order to reduce dosing frequency.

O autorze

Jagtap, Rajesh
Mr. Rajesh Jagtap is currently working as an Assistant Professor & Vice-Principal at Annasaheb Dange college of B Pharmacy, Ashta. He has a total of 11 years teaching experience. He has published more than 20 papers in reputed national & international journals and also presented more than 10 papers in national & international conference.