Concepts and Applications in Veterinary Toxicology: An Interactive Guide

ISBN-13: 9783030222499 / Angielski / Twarda / 2019 / 350 str.

Pawan Kumar Gupta

Recenzje

“The book is intended primarily for veterinary toxicologists, veterinary practitioners, toxicology residents, and students new to the field of veterinary toxicology. It also is a useful resource for faculty in academic institutions teaching veterinary toxicology. … This book offers a good summary of key concepts in toxicology. It serves as a useful resource for people who need to review or have a quick reference on the basic concepts of toxicology.” (Juanmahel Davila, Doody’s Book Reviews, January 10, 2020)

Spis treści

Chapter 1: GENERAL AND PRINCIPLES OF TOXICOLOGY

1.0 Introduction 2.0 Key Points 4.0 Roots in Veterinary Medicine and Toxicology 5.0 Current Status 6.0 Toxicology and the Risk of Paradigm

7.0 Definitions and Classification of Toxic Agents

8.0 Factors Affecting the Activity of Toxicants

    8.1 Factors related to Exposure

    8.2 Biological Factors

    8.3 chemical factors

9.0 Natural Law Concerning Toxicity 

    9.1 Dose-Response Relationship

   9.2 Statistical Concept of Toxicity    9.3 Variables of Dose-Response Curves     9.4 Interaction with Receptors

10.0 Brain Storming Exercises

    10. 1 Short Questions and Answers

    10.2 Multiple Choice Questions

    10.3 Fill in the Blanks

    10.4 True or False Statements

    10.5 Match the Statements

 11.0 Answers to Exercises

   11.1 Multiple Choice Questions

   11.2 Fill in the Blanks

   11.3 True or False Statements

   11.4 Match the Statements

12. Further Reading

Chapter 2: MECHANISM OF TOXICITY

1.0    Introduction 2.0 Key Points 3.0 Definitions 4.0 Mode of Action 5.0 Mechanism of Toxicity

6.0 Brain Storming Exercises

     6.1 Short Questions and Answers

    6.2 Multiple Choice Questions

    6.3 Fill in the Blanks

    6.4 True or False Statements

    6.5 Match the Statements

7.0 Answers to Exercises

    7.1 Multiple Choice Questions

    7.2 Fill in the Blanks

    7.3 True or False Statements

    7.4 Match the Statements

8.0. Further Reading

Chapter 3: DISPOSITION AND TOXICOKINETICS                 

1.0 Introduction 2.0 Key Points 3.0 Absorption, 4.0 Distribution, 5.0 Biotransformation / metabolism       5.1 Phase I Reactions       5.2 Phase I Reactions 5.3 Elimination 6.0 Induction and Inhibition of Metabolizing Enzymes 7.0 Bioactivation and Tissue Toxicity 8..0 Essentials of Toxicokinetic/Pharmacokinetic Principles 9.0 Plasma Drug Concentration versus Time 10.0 Orders of Rate Processes 11.0 Toxicokinetic Models 12.0 Determination of Dose/Dosage Regimen 13.0 Brain Storming Exercises

    13. 1 Short Questions and Answers

    13.2 Multiple Choice Questions

    13.3 Fill in the Blanks

    13.4 True or False Statements

    13.5 Match the Statements

14.0 Answers to Exercises

    14.1 Multiple Choice Questions

    14.2 Fill in the Blanks

    14.3 True or False Statements

    14.4 Match the Statements

15.0 Further Reading

CHAPTER 4 : TOXIC EFFECTS OF PESTICIDES (AGROCHEMICALS)

1.0 Introduction 2.0 Key Points 3.0 Historical Background 4.0 Definition and Classification 5.0 Toxicity Rating 6.0 Insecticides 6.0 Herbicides 7.0 Fungicides 8.0 Rodenticides 9.0 Fumigants

10.0 Fertilizers

11.0 Epidemiology of Poisonings 12.0 Brain Storming Exercises

    12.1 Short Questions and Answers

    12.2 Multiple Choice Questions

    12.3 Fill in the Blanks

    12.4 True or False Statements

    12.5 Match the Statements

13.0 Answers to Exercises

    13.1 Multiple Choice Questions

    13.2 Fill in the Blanks

    13.3 True or False Statements

    13.4 Match the Statements

14.0 Further Reading

CHAPTER 5: TOXIC EFFECTS OF METALS AND MICRONUTIENTS 1.0 Introduction 2.0 Key Points 3.0 Arsenic  (Sankhyal, Somalkar) 4.0 Cadmium 5.0 Chromium, Iodine, and Phosphorus 6.0 Copper 7.0 Fluoride 8.0 Iron 9.0 Lead 10.0 Mercury 11.0 Molybdenum 12.0 Selenium 13.0 Salt Poisoning/Deficiency 14.0 Sulfur 15.0 Zinc 16.0 Brain Storming Exercises

    16. 1 Short Questions and Answers

    16.2 Multiple Choice Questions

    16.3 Fill in the Blanks

    16.4 True or False Statements

    16.5 Match the Statements

17.0 Answers to Exercises

    17.1 Multiple Choice Questions

17.2 Fill in the Blanks

    17.3 True or False Statements

    17.4 Match the Statements

18.0 Further Reading

Chapter 6: Toxicologic Hazards of GASES, vapors and other Chemicals 1.0 Introduction 2.0. Key Points

3.0 Chemicals

    3.1 Alcohol

    3.2 Ethylene Glycol

     3.3 Propylene Glycol

     3.4 Corrosive Bleaches

     3.5 Detergents Soaps and Shampoos

4.0 Petroleum Products

5.0 Persistent Halogenated Aromatic

6. Coal Tar Products

7. Pentachlorophenol product

7. Gasses

8. Carbon Monoxide 7. Cyanide poisoning 8.0 Hydrogen Sulfide 9.0 Nitrogen Dioxide 10 Phosphine Gas Sources 11.0 Lack of Oxygen

12.0 Smoke inhalation

13.0 Brain Storming Exercises

  13. 1 Short Questions and Answers

   13.2 Multiple Choice Questions

   13.3 Fill in the Blanks

   13.4 True or False Statements

  13.5 Match the Statements

14.0 Answers to Exercises

    14.1 Multiple Choice Questions

   14.2 Fill in the Blanks

   14.3 True or False Statements

   14.4 Match the Statements

15.0 Further Reading

CHAPTER 7: TOXICITIES FROM HUMAN DRUGS 1.0 Introduction 2.0 Key Words 3 Toxicities from Over-the-Counter Drugs 4.0 Toxicities from Prescription Drugs 5.0 Toxicities from Illicit and Abused Drugs 6.0 Brain Storming Exercises

   6. 1 Short Questions and Answers

   6.2 Multiple Choice Questions

   6.3 Fill in the Blanks

   6.4 True or False Statements

   6.5 Match the Statements

7.0 Answers to Exercises

   7.1 Multiple Choice Questions

   7.2 Fill in the Blanks

   7.3 True or False Statements

    7.4 Match the Statements

8.0 Further Reading

CHAPTER 8: POISONOUS AND VENOMOUS ORGANISMS 1.0 Introduction 2.0 Key Points 3.0 Arthropods 4.0 Amphibia, Anura: Toads 5.0 Brain Storming Exercises

   5. 1 Short Questions and Answers

   5.2 Multiple Choice Questions

   5.3 Fill in the Blanks

   5.4 True or False Statements

   5.5 Match the Statements

6.0 Answers to Exercises

   6.1 Multiple Choice Questions

   6.2 Fill in the Blanks

   6.3 True or False Statements

    6.4 Match the Statements

7. Further Reading

CHAPTER 9: BACTERIAL AND CYANOBACTERIAL (BLUE-GREEN ALGAE) 1.0 Introduction 2.0 Key Points 3.0 Botulinum toxins 4.0 Entero Toxemias (Clostridium perfringens infections) 5.Blue-Green Algae (Cyanobacterial Toxins) 6.0 Brain Storming Exercises

   6. 1 Short Questions and Answers

   6.2 Multiple Choice Questions

   6.3 Fill in the Blanks

   6.4 True or False Statements

   6.5 Match the Statements

7.0 Answers to Exercises

   7.1 Multiple Choice Questions

   7.2 Fill in the Blanks

   7.3 True or False Statements

    7.4 Match the Statements

8.0 Further Reading

CHAPTER 10: MYCOTOXICOSIS 1 Introduction 2. Key Points 3. Aflatoxicosis 4. Ochratoxin A 5. Ergotism 6. Estrogenism and Vulvovaginitis 7. Facial Eczema 8. Fescue Lameness (Fescue foot) 9. Fumonisin Toxicosis 10. Mycotoxic Lupinosis 11Trichothecene Toxicosis

12. Paspalum Staggers

13.0 Slaframine Toxicosis

14.0 Brain Storming Exercises

    14. 1 Short Questions and Answers

    14.2 Multiple Choice Questions

    14.3 Fill in the Blanks

    14.4 True or False Statements

    14.5 Match the Statements

15.0 Answers to Exercises

    15.1 Multiple Choice Questions

    15.2 Fill in the Blanks

    15.3 True or False Statements

    15.4 Match the Statements

16.0 Further Reading

CHAPTER 11: POISONOUS PLANTS 1 Introduction 2 Key Points 3. Astragalus and Oxytropis Species 4 Nitro-containing Astragalus (milkvetches) 5 Seleniferous Astragalus 6 Larkspurs (Delphinium Spp.) 7 Lupines (LUPINUS Spp.) 8 Poison Hemlock (Conium Maculatum) 9 Water Hemlock (Cicuta Spp.) 10 Ponderosa Pine Needles (Pinus Spp.) 11 Broom Snakeweed (Gutierrezia Spp.) 12 Rayless Goldenrod (Haplopappus Heterophyllus) 13 Halogeton (Haloģeton G¸ Lomeratus) 14 Pyrrolizidine Alkaloid Containing Plants 15 Photosensitizing Plants 16 Bracken Fern (Pteridium and Aquilinum) 17 Cannabis Sativa (Cannabinaceae Family) 18 Colchicum Autumnale L (Liliaceae or Colchicaceae Family)

19 Datura Spp. (Solanaceae Family)

20 Nerium Oleander (Apocynaceae Family) 21 Aconitum napellus (Ranunculaceae Family) 22 Ricinus Communis (Euphorbiaceae Family) 23 Lantana (Verbenaceae, Family) 24 Descurainia Pinnata (Family Brassicaceae) 25 Plants Containing Cyanogenic Glycosides 26 Nitrate- and Nitrite-Accumulating Plants 27 Toxicity of Yew (Taxus spp.) Alkaloids 28 Mushroom Toxins 29.0 Brain Storming Exercises

    29. 1 Short Questions and Answers

    29.2 Multiple Choice Questions

    29.3 Fill in the Blanks

    29.4 True or False Statements

    29.5 Match the Statements

30.0 Answers to Exercises

    30.1 Multiple Choice Questions

    30.2 Fill in the Blanks

    30.3 True or False Statements

    30.4 Match the Statements

31.0 Further Reading

CHAPTER 12: FEED CONTAMINANT TOXICITY 1.0 Introduction 2.0 Key Points 3.0 Melamine and Cyanuric Acid 4.0 Ionophore Toxicity  5.0 Nonprotein Nitrogen Poisoning 6.0 Brain Storming Exercises

    6. 1 Short Questions and Answers

    6.2 Multiple Choice Questions

    6.3 Fill in the Blanks

    6.4 True or False Statements

    6.5 Match the Statements

7.0 Answers to Exercises

    7.1 Multiple Choice Questions

    7.2 Fill in the Blanks

    7.3 True or False Statements

    7.4 Match the Statements

8.0 Further Studies

CHAPTER 13: FOOD HAZARDS 1.0 Introduction 2.0      Key Points 3.0   Avocado 4.0    Beard Doughs 5.0    Chocolate 6.0    Macadamia Nuts 7.0    Xylitol 8.0    Raisins and Grapes 6.0 Brain Storming Exercises

    6. 1 Short Questions and Answers

    6.2 Multiple Choice Questions

    6.3 Fill in the Blanks

    6.4 True or False Statements

    6.5 Match the Statements

7.0 Answers to Exercises

    7.1 Multiple Choice Questions

    7.2 Fill in the Blanks

    7.3 True or False Statements

    7.4 Match the Statements 

8.0 Further Studies

CHAPTER 14: VETERINARY CLINICAL TOXICOLOGY 1.0 Introduction 2.0 Key Points 3.0 Concepts and Terminology  4.0 .Prevention and Management
4. Diagnosis of  Toxicosis 
5. Principles of Therapy 6.0 Brain Storming Exercises

    6. 1 Short Questions and Answers

    6.2 Multiple Choice Questions

    6.3 Fill in the Blanks

    6.4 True or False Statements

    6.5 Match the Statements

7.0 Answers to Exercises

    7.1 Multiple Choice Questions

    7.2 Fill in the Blanks

    7.3 True or False Statements

    7.4 Match the Statements 8.0. Further Reading.

 

O autorze

Prof. Dr. Gupta is an internationally known toxicologist with more than 54 years of experience in the field of teaching, research and as research management in toxicology. He has guided many post-graduate students for their thesis work in toxicology and was honored with several National and International Awards including best teachers, best researcher, Alarsin, Lifetime achievements, UP Book of Records, Limca Book Records  and IUTOX-Astra Zeneca Award (USA). To his credit he has several books, book chapters (John Wiley, Elsevier, Academic Press, Merck & Co. Mariel Limited and Springer USA) as well as scientific research publications (705) published in National and International peer reviewed Journals of repute. His contribution in the publication of Indian Veterinary Pharmacopeia is highly praise worthy. He is the founder Editor-in-Chief of a peer reviewed scientific journal “Toxicology International”, and has been the Book Review Editor, Marcel Dekker, USA; Expert member Consultant and Advisor to WHO, Geneva; Consultant United Nations FAO, Rome; IAEA, Vienna; Founder Academy of Sciences for Animal Welfare; Founder and Past President, Society of Toxicology of India; Adjunct Professor, SRMS; founder director and member nominating committee of International Union of Toxicology; founder President of Society of Toxicology of India, founder Editor-in-Chief of peer reviewed PUBMED indexed scientific Journal “Toxicology International, and has held several prominent positions of scientific organizations in India and abroad. In addition to this Dr. Gupta has also been biographer in several WHO's WHO from all over the world including Marquis WHOs WHO (USA), IBC (UK) and other leading publications of the World. Dr Gupta has been President of Rotary Club, International Distict 3110. At present Dr. Gupta is Director of Toxicology Consulting Group, Patron and Founder President of the Society of Toxicology of India, and President of the Academy of Sciences for Animal Welfare. Dr. Gupta has widely traveled all over in USA, Canada, Mexico, Great Britain, Belgium, Nepal, The Netherlands, France, Germany, Switzerland, Croatia, Italy, Hong Kong, Ireland, Russia, Thailand, China, etc. to visit their laboratories and to deliver lectures (visiting Professor, University of Tennessee and West Virginia University, USA) in specialty areas of toxicology.

Blurb

This book: “Concepts and Applications in Veterinary Toxicology: An Interactive Guide”: covers a broad spectrum of topics related to students specializing in veterinary toxicology and for veterinary medical practitioners. Since the major emphasis of the book is to teach veterinary students, therefore more attention has been given to common toxicants to which several species are exposed including pet animals. The subject of veterinary toxicology is complicated greatly by the wide variations in responses of domestic, companion, aquatic, wild, and zoo species to toxicants. Therefore, emphasis has also been given to species variation and diagnostic toxicology including clinical management that is more relevant to veterinary profession.

Key Features

·  Highlights specialized topics essential for veterinary specialists.

·   Covers a variety of common toxicants to which several species including pet animals are exposed.

· Includes sample questions and answers that are extremely valuable for students, clinical pharmacists, teachers, and academicians in preparing for their board and other examinations.