Computer Techniques in Preclinical and Clinical Drug Development

ISBN-13: 9780849376825 / Angielski / Twarda / 1996 / 256 str.

Robert C. Jackson;Jackson

Opis

This text responds to the question how can we use computational methods to improve the success rate in drug development?. It aims to show how modelling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modelling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics and inhibition kinetics of mulienzyme pathways are all discussed.

Spis treści

Introduction: The Preclinical and Clinical Drug Development Process Physiological Pharmacokinetic Modeling Interspecies Scaling Prediction of Drug Metabolism and Toxicity Pharmacodynamic Modeling Cytokinetic Modeling Prediction of Drug Resistance Conclusions: The Virtual Clinical Trial References Appendix: Computational Pharmacology Software Suppliers Abbreviations Index

O autorze

Jackson, Robert C.