Comparative Chemical Mutagenesis

ISBN-13: 9781461334118 / Angielski / Miękka / 2011 / 1117 str.

Frederick De Serres

Opis

Frederick J. de Serres, Ph. D. Office of the Associate Director for Genetics National Institute of Environmental Health Sciences Research Triangle Park, North Carolina (U. S. A. ) 27709 The Workshop on Comparative Chemical Mutagenesis was orga- nized to begin the process of problem identification and resolution concerning our needs to evaluate the data on test chemicals arising from assays for mutagenic activity on laboratory organisms. In the past, data on chemical mutagens has been generated and published in the scientific literature on a more or less random basis. Individual chemicals enjoy a brief period of "popularity" that leads to a burst of publications in the same or sometimes related assay systems. The incompleteness of the data base, in many of these cases, makes comparative mutagenesis difficult or impossible. In our attempts to compare the genetic effects of a given chemical over a wide range of assay systems, we are often interested in making quantitative as well as qualitative compari- sons. To restate the first comparison: is the chemical under ques- tion a weak, moderate or potent mutagen over a wide range of assay systems--or alternatively, does the level of response vary markedly? To make the second comparison, what is needed is information on the spectrum of genetic alterations produced as well as whether this spectrum is consistent over a wide range of organisms.

Spis treści

1 Introduction.- Group 1 -- Analysis of Genetic Effects by Test System.- 2 Mutagenicity of Selected Chemicals in in Escherichiacoli DNA Repair Deficient Assays.- 3 Mutagenicity of Selected Chemicals in the Rec-Assay in Bacillussubtilis.- 4 Mutagenicity of Selected Chemicals in the Salmonella/Microsome Mutagenicity Test.- 5 Mutagenicity of Selected Chemicals in Escherichiacoli Test Systems.- 6 Mutagenicity of Selected Chemicals in Neurosporacrassa.- 7 Mutagenicity of Selected Chemicals in Yeast: Mutation-Induction at Specific Loci.- 8 Mutagenicity of Selected Chemicals in Yeast: Mitotic Recombination, Gene Conversion, and Nondisjunction.- 9 Mutagenicity of Selected Chemicals in Drosophila.- 10 Mutagenicity of Selected Chemicals in Soybean Test Systems.- 11 Mutagenicity of Selected Chemicals in Barley Test Systems.- 12 Mutagenicity of Selected Chemicals in Barley: Repair and Recovery.- 13 Mutagenicity of Ethyl Methanesulfonate, Mitomycin C, and Vinyl Chloride in the Tradescantia Test Systems.- 14 Mutagenicity of Selected Chemicals in Viciafaba and Alliumcepa Test Systems.- 15 Mutagenicity of Selected Chemicals in the Host-Mediated Assay.- 16 Mutagenicity of Selected Chemicals in Specific Loci of Cultured Mammalian Cells.- 17 Mutagenicity of Selected Chemicals in Mammalian In Vitro Cytogenetic Systems.- 18 Mutagenicity of Selected Chemicals in the Mammalian Dominant Lethal Assay.- 19 Mutagenicity of Selected Chemicals in Sister-Chromatid Exchange Assays.- 20 Mutagenicity of Selected Chemicals in In Vivo Cytogenetic Assays.- 21 Mutagenicity of Selected Chemicals in Unscheduled DNA Synthesis Assays.- 22 Mutagenicity of Selected Chemicals in the Mammalian Micronucleus Test.- 23 Mutagenicity of Selected Chemicals in Mammals: The Heritable Translocation Test.- 24 Mutagenicity of Selected Chemicals in the Mammalian Spot Test.- 25 Mutagenicity of Selected Chemicals in Induction of Specific Locus Mutations in Mice.- Group 2 -- Analysis of Genetic Effects by Test Chemical.- 26 Comparative Mutagenicity of Methyl Methanesulfonate and Ethyl Methanesulfonate.- 27 Comparative Mutagenicity of Dimethylnitrosamine and Diethylnitrosamine.- 28 Comparative Mutagenicity of Aflatoxin Bl and Vinyl Chloride.- 29 Comparative Mutagenicity of N-Methyl-N?-Nitro-N-Nitrosoguanidine and ICR-170.- 30 Comparative Mutagenicity of Myleran and Cyclophosphamide.- 31 Comparative Mutagenicity of TEPA, ThioTEPA, and MeTEPA.- 32 Comparative Mutagenicity of TEM, Trenimon and Ethylenimine.- 33 Comparative Mutagenicity of Procarbazine (Natulan).- 34 Comparative Mutagenicity of Mitomycin C.- 35 Comparative Mutagenicity of Epichlorohydrin and Cadmium.- Risk Estimation.- 36 Comparative Chemical Mutagenicity: Can We Make Risk Estimates?.- 37 Establishment of Requirements for Estimation of Risk for the Human Population.