Companion Diagnostics (CDX) in Precision Medicine

ISBN-13: 9789814800235 / Angielski / Twarda / 2019 / 256 str.

Il-Jin Kim

Opis

This book covers the technical, historical, clinical, and regulatory aspects of CDx in precision medicine. Clearly, more and more newly developed oncology drugs will require accompanying CDx assays, and this book, with chapters contributed by renowned oncologists.

Spis treści

Overview of Companion Diagnostics (CDx) for Precision Medicine.  Companion Diagnostic (CDx) Tests in Clinical Laboratory Improvement Amendments (CLIA)-Certified Laboratories.  Quantitative Polymerase Chain Reaction for Companion Diagnostics and Precision Medicine Application.  Protein Biomarker Signatures in Precision Diagnostics of Cancer.  Next-Generation Sequencing (NGS) for Companion Diagnostics (CDx) and Precision Medicine.  Molecular Pathologic Diagnostics for Personalized Medicine.  Establishment and Characterization of Cancer Cell Lines for Companion Diagnostics.  Companion Diagnostics for Oncogenic Fusion Proteins.  Clinical Trial Designs for Testing Companion Diagnostics (CDx).  Companion Diagnostics and Precision Medicine for Colorectal Cancer.  Molecular Diagnostics of Chronic Myeloid Leukemia: Precision Medicine via Gold Nanoparticles. Adaptive Resistance Mechanisms in EGFR Mutant NSCLC.