Communication Within Animal Cells

ISBN-13: 9780198547266 / Angielski / Miękka / 1992 / 360 str.

Greg J. Barritt

Opis

The ordered growth and functioning of animal cells requires the transfer of information from one part of the cell to another. This information comes from a bewildering variety of sources, both within and outside the cell. Hormones, neurotransmitters, growth factors and extracellular metabolites interact with specific receptors on the plasma membrane or in the cytoplasm. Inside the cell, information is relayed by intracellular messengers, including cyclic nucleotides, inositol polyphosphates, diacylglycerol and calcium, and by GTP-binding proteins, protein kinases, and DNA-binding proteins. Finely balanced interactions between these different signalling pathways ensure that the required response occurs, and abnormalities in any of the components of the system can lead to a variety of diseases, including cancer. This textbook brings together and puts into perspective a large body of knowledge about intracellular signalling systems. Written in a clear and authoritative style, with many illustrations, it will be invaluable to students on advanced undergraduate and graduate courses. It also provides a detailed introduction to and review of this central topic for researchers in cell biology and related disciplines.

Recenzje

'Those who have had the good fortune to be taught by Professor Barritt as undergraduates well remember the wonderful clarity of his lectures, the flow of the ideas he presented and the delight of his lecture notes ... his book on "Communication Within Anmimal Cells" is a delight to read, not only for its scientific content but also for its flawless presentation. Such is the style of the presentation ... that the reader finishes it feeling that he has gained enormously in scientific concepts at the cost of an embarassingly small effort. Cleanly flowing text coupled with an abundance of uncluttered line drawings allow the ideas to form effortlessly in the reader's understanding ... wide ranging text ... a book which deserves to be widely read.' Richard G. Ryall, Women's and Children's Hospital, Adelaide, The Clinical Biochemist Newsletter, March 1993

Spis treści

Networks of extracellular and intracellular signals; Role of cell structure in intracellular communication; The plasma-membrane receptors and GTP-binding proteins; The protein kinases and phosphatases; The cyclic nucleotides; The inositol polyphosphates and diacylglycerols; Calcium; The intermediary metabolites; Metabolites of arachidonic acid; Sequence-specific DNA-binding proteins; The oncogenes; Interactions between pathways of intracellular communication; Index