Commercial Plant-Produced Recombinant Protein Products: Case Studies

ISBN-13: 9783662522950 / Angielski / Miękka / 2016 / 281 str.

John a. Howard; Elizabeth E. Hood

Opis

Attention has recently turned to using plants as hosts for the production of commercially important proteins. There are many indications that plant protein production marks the beginning of a new paradigm for the commercial production of proteins that, over the next decade, will expand dramatically.

Spis treści

1 Introduction — Plant-produced protein products

Elizabeth E. Hood and Paul Christou

Part I: Highly Purified Proteins

2 Commercial Plant-Produced Recombinant Avidin

Elizabeth E. Hood and John A. Howard

3 Molecular farming in plants – the long road to the market

Rainer Fischer, Johannes F Buyel, Stefan Schillberg and Richard M Twyman

4 TrypZean™: an animal-free alternative to bovine trypsin

Aparna Krishnan, Susan L. Woodard

5 Production of Pharmaceutical Grade Recombinant Native Aprotinin and Non-Oxidized Aprotinin-Variants Under Greenhouse and Field Conditions

Gregory P. Pogue, Fakhrieh Vojdani, Kenneth E. Palmer, Earl White, Hugh Haydon, Barry Bratcher

Part II: Vaccines

6 Influenza virus-like particles produced in Nicotiana benthamiana protect against a lethal viral challenge in mice

Louis-P Vézina, Brian J Ward, Marc-André D’Aoust, Manon Couture, Sonia Trépanier, Andrew Sheldon1, Nathalie Landry

7 Plant-Produced Recombinant Transmission Blocking Vaccine Candidates to Combat Malaria

Stephen J. Streatfield, Natasha Kushnir, Vidadi Yusibov

8 An oral vaccine for TGEV immunization of pigs

Rajan, V.

9 Edible Rabies Vaccines

Elizabeth Loza-Rubio and Edith Rojas-Anaya

10 Newcastle disease vaccines

Miguel A. Gómez Lim

11 An oral vaccine for hepatitis B: challenges, setbacks, and breakthroughs

Celine A. Hayden

Part III: Industrial Proteins

12 Commercial Plant-Produced Recombinant Cellulases for Biomass Conversion

Elizabeth E. Hood, Deborah V. Requesens

13 Brazzein: A High Intensity Natural Sweetener

Gina Fake and John Howard

Part IV: Future Directions

14 The Future of Plant-Produced Pharmaceuticals and Industrial Proteins

John Howard, Elizabeth E. Hood

Blurb

Attention has recently turned to using plants as hosts for the production of commercially important proteins. The twelve case studies in this volume present successful strategies for using plants to produce industrial and pharmaceutical proteins and vaccine antigens. They examine in detail projects that have commercial potential or products that have already been commercialized, illustrating the advantages that plants offer over bacterial, fungal or animal cell-culture hosts. There are many indications that plant protein production marks the beginning of a new paradigm for the commercial production of proteins that, over the next decade, will expand dramatically.