Combination Studies with the Vascular Disrupting Agent Ca4p

ISBN-13: 9783838343532 / Angielski / Miękka / 2011 / 256 str.

Andrew Gaya

Opis

This work represents studies carried out at Mount Vernon Hospital and UCL, and sponsored by Cancer Research UK, between 2003 and 2006. Phase I/II Clinical trial studies of the vascular disrupting agent Combretastatin A4 Phosphate (CA4P) are presented - in combination with cytotoxic chemotherapy (Paclitaxel and Carboplatin), and radioimmunotherapy. Dynamic Contrast Enhanced MRI data from the studies is presented and discussed, and a supporting immunohistochemistry correlation study of vascular markers is also presented.

O autorze

Dr Gaya is a Clinical Oncologist at Guy's and St Thomas' Hospitals in London. He has completed an MD at UCL of which this work is a summary. He treats patients with GI cancers and is continuing to pursue an interest in functional imaging of cancers.