Cologne Atherosclerosis Conference No. 2: Lipids: 2nd Cologne Atherosclerosis Conference, Cologne, May 2-4, 1984

ISBN-13: 9783034872379 / Angielski / Miękka / 2012 / 242 str.

Parnham

Opis

This book contains the proceedings of the 2nd Cologne Ath roscle- rosis Conference (CAC) which was devoted to lipids, in particular lipoproteins. The object of the conference series, organised by A. Nattermann & Cie. GmbH, Cologne, is to provide an overview of various fields either directly related to or associated with the process of atherosclerosis. Having considered the associated field of inflammation in the first conference, the 2nd CAC dealt with a subject intimately related to the atherosclerotic process per see The recent demonstration in an extensive clinical study of a close link between high plasma cholesterol and coronary mortality has awakened both the medical and the lay communities to the importance of research into lipoprotein biochemistry and physiology. This can only be good news since more intensive research into lipoprotein functions is vital for future therapy of atherosclerosis and other lipid disorders. The status of research on lipoproteins is reflected in the contributions to this book, which are of an interdisciplinary nature, including both reviews and shorter research reports by acknowledged experts in the field. Special thanks are due to Margret Leffin for her organisational and secretarial assistance at all stages and to Dr. D. Bowyer and Prof. W. Stoffel for their advice and assist- ance with the programme. Cologne, July 1984 Michael J -. Parnham Lipoprotein Synthesis and Receptor Interactions 17 AAS 16: 2nd Cologne Atherosclerosis Conference 1984 (c) 1984 Birkhiiuser Verlag Basel APOLIPOPROTEIN GENES, DNA POLYMORPHISMS AND HYPERLIPIDEMIA c. c. Shoulders and F. E.

Spis treści

Lipoprotein Synthesis and Receptor Interactions.- Apolipoprotein genes, DNA polymorphisms and hyperlipidaemia.- The use of recombinant DNA technology to study polygenic hyperlipidaemia.- Lipoprotein synthesis (Abstract only).- The LDL receptor in lipoprotein turnover (Abstract only).- Receptor interactions controlling lipoprotein metabolism (Abstract only).- A saturable binding site for high density lipoprotein3 on human liver membranes.- Lipoprotein Metabolism.- Lipoprotein lipase — the molecule and its interactions.- Organ specific metabolism of low density lipoprotein and high density lipoprotein.- Metabolism of rat serum high-density lipoprotein apolipoprotein A-IV.- Importance of particle size and lipid composition in the transfer of plasma apolipoproteins to microemulsions.- The role of lysophosphatidylcholine in the regulation of the catabolism of triglyceriderich lipoproteins.- Hypercholesterolemic and diabetic serum decrease LDL-degradation by cathepsin D from human arterial smooth muscle cells and fibroblasts.- Metabolic channelling of apolipoprotein B in very low density lipoprotein.- Turnover of APOB in low density lipoprotein sub-fractions.- Lipoproteins and Macrophages.- Degradation of normal and abnormal plasma lipoproteins by cultured macrophages.- The role of macrophages in atherosclerosis (Abstract only).- The role of the monocyte/macrophage system in lipoprotein metabolism.- Solubilization and purification of an acetyl-LDL binding membrane protein from human leukocytes.- The effect of LDL and modified LDL on macrophage secretion products.- Macrophages, oxidised lipids and atherosclerosis.- Clinical Aspects.- Regulation of low density lipoprotein uptake and degradation in different animal species.- Regulation of LDL receptors in vivo.- Familial hypercholesterolemia proven by tissue culture and atherosclerosis in relation to other risk factors.- Familial hypertriglyceridemia and the regulation of lipid synthesis by insulin and triiodothyronine in human cell cultures.- Mutations of apolipoprotein AI can affect cofactor function for cholesteryl ester formation by lecithin: cholesterol acyltransferase.- Oral administration of polyunsaturated phosphatidylcholine reduces lipid and cholesterol contents in platelets of healthy volunteers.- Influence of age, body-weight, smoking habits and alcohol consumption on the lipoprotein profile: preliminary results from a study performed on 6543 male industrial workers aged 40–59 years.