Colloid and Interface Science in Pharmaceutical Research and Development

ISBN-13: 9780444626141 / Angielski / Twarda / 2014 / 532 str.

Hiroyuki Ohshima

Opis

Colloid and Interface Science in Pharmaceutical Research and Development describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement. The book starts with fundamentals in Part I, covering fundamental aspects of colloid and interface sciences as applied to pharmaceutical sciences and thus should be suitable for teaching. Parts II and III treat applications and measurements, and they explains the application of these properties and their influence and use for the development of new drugs.

• Provides a clear description of the fundamentals of colloid and interface science relevant to drug research and development
• Explains the physicochemical/colloidal basis of pharmaceutical science
• Lists modern experimental characterization techniques, provides analytical equations and explanations on analyzing the experimental data
• Describes the most advanced techniques, AFM (Atomic Force Microscopy), SFA (Surface Force Apparatus) in detail

Spis treści

Part I Fundamentals

Interaction between drugs

Pharmaceutical suspensions

Response of colloidal drugs to external fields

Aggregation of drugs

Concentrated drug particles

Rheology of colloidal suspensions

Part II Applications of Colloid and Interface Science in Pharmaceutical sciences

Liposomes and micelles

Binding of drugs on liposomes

Drug delivery system

Gold nanoparticles

Drug permeation through biological membranes

EPR effects

Part III Measurements

Zeta potential of colloidal drugs

Atomic force microscope

Surface force apparatus