Coenzyme Q: Molecular Mechanisms in Health and Disease

ISBN-13: 9780849387326 / Angielski / Twarda / 2000 / 408 str.

Valerian E. Kagan; Valerian E. Kagan; Peter J. Quinn

Opis

Since its discovery in 1957, Coenzyme Q has piqued the interest of scientists from a wide range of disciplines because of its bioenergetics, vitamin-like behavior, and interactions with antioxidant vitamins E and C. Coenzyme Q: Molecular Mechanisms in Health and Disease is a comprehensive treatise on this often-studied coenzyme. International experts cover the research that led to its emergence as an exciting, new dietary supplement.The present volume summarizes the latest developments in various areas of CoQ research. New concepts on extramitochondrial functions of CoQ are discussed in two chapters, while recent discoveries in biosynthetic pathways for CoQ based on molecular genetic approaches are presented in another chapter.Further chapters explore the role of CoQ as an antioxidant, revealing the need for additional research in this exciting area. This book will be of extreme interest to biochemists, biophysicists, molecular and cell biologists, as well as nutritionists and biomedical health workers.

Recenzje

"…well written and well referenced, especially the chapters on the chemical and physical properties of coenzyme Q and its functions…mechanisms of coenzyme Q and genetic analysis of coenzyme Q biosynthesis…is timely and the book should serve as an excellent reference for biochemists, nutritionists, clinicians and other biomedical researchers interested in coenzyme Q. It complements other coenzyme Q publications well."
--Ching K. Chow, Graduate Center for Nutritional Sciences, University of Kentucky, in ScholarOne.com

Spis treści

MOLECULAR MECHANISMS OF COENZYME Q
Chemical and Biophysical Properties
Biochemical Mechanisms in Electron transport in Mitochondria and Extramitochondrial Locations
Antioxidant Mechanisms
Prooxidant Mechanisms
NUTRITIONAL ASPECTS OF COENZYME Q
Biosynthesis and Nutritional Sources
Dietary Supplementation and Plasma/Tissue Concentrations
HEALTH EFFECT OF COENZYME Q. Coenzyme Q Status and Oxidative Stress in Vivo
Cardiovascular Pathology
Liver Injury
Physical Performance/Training
Aging

O autorze

Valerian E. Kagan, Peter J. Quinn