Clinical Trials in Parkinson's Disease

ISBN-13: 9781071609149 / Angielski / Miękka / 2021 / 396 str.

Santiago Perez-Lloret

Spis treści

Series Preface…

Dedication…

Preface…

Table of Contents…

Contributing Authors…

Part I Preclinical Models of Parkinson’s Disease

1. Toxin-Based Rodent Models of Parkinson’s Disease

M. Angela Cenci Nilsson and Véronique Sgambato

2. Assessment of Non-Motor Symptoms in Rodent Models of Parkinson’s Disease

Francesca Rossi, Manolo Carta, and Elisabetta Tronci

3. Genetic Models of Parkinson’s Disease 

Philippe Kachidian and Paolo Gubellini

Part II Clinical Trials for Motor Symptoms in Parkinson’s Disease

4. A Review of Randomized Phase III Pharmacological Clinical Trials for Motor Symptoms in Parkinson’s Disease Patients and Quality of Evidence Recommendations

Mónica M. Kurtis, Carmen Rodriguez-Blazquez, and Isabel Pareés

5. Clinical Trials for Motor Complications in Parkinson’s Disease

Tiago A. Mestre, Joaquim J. Ferreira, and Olivier Rascol

6. Clinical Trials for Gait Disorders in Parkinson’s Disease

Zuzana Kosutzka, Urban M. Fietzek, and Peter Valkovic

7.  Clinical Trials for Disease Modifying Agents in Parkinson’s Disease

Orlando Artavia and Lana Chahine

8. Value and Methods of Pharmacovigilance in the Monitoring of Drug Safety in Parkinson’s Disease

Santiago Perez-Lloret, James A.G. Crispo, Maria Veronica Rey, Donald Mattison, and Daniel Krewski

Part III Clinical Trials for Non-Motor Symptoms in Parkinson’s Disease

9. Clinical Trials for Cognitive Impairment and Dementia in Parkinson’s Disease

Brandon Barton

10. Clinical Trials for Depression, Anxiety, Fatigue, and Apathy in Parkinson’s Disease

Matej Skorvanek and Marek Balaz

11. Clinical Trials for Sleep Disorders and Daytime Somnolence in Parkinson’s Disease

Marissa N. Dean and Amy W. Amara

12. Clinical Trials on Management of Pain in Parkinson’s Disease

Azman Aris, Raquel Taddei, Alexandra Rizos, Anna Sauerbier, and K. Ray Chaudhuri

13. Clinical Trials for Orthostatic Hypotension in Parkinson’s Disease and Other Synucleinopathies 

Jose-Alberto Palma and Horacio Kaufmann

14. Clinical Trials for Erectile Dysfunction in Parkinson's Disease

Shen-Yang Lim, Ai Huey Tan, and Mathis Grossmann

15. Clinical Trials for Constipation in Parkinson’s Disease

Patricio Millar Vernetti

Subject Index List…

Blurb

This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center.

Cutting-edge and authoritative, Clinical Trials in Parkinson’s Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials.