Clinical Trial Optimization Using R

ISBN-13: 9781498735070 / Angielski / Twarda / 2017 / 319 str.

Alex Dmitrienko; Erik Pulkstenis

Opis

The main goal of this book is to define a unified framework for clinical trial optimization based on a comprehensive quantitative evaluation of relevant clinical scenarios (using the clinical scenario evaluation approach) and introduce best practices for simulationbased optimization. The book will be aimed at a broad audience and will emphasize a hands-on approach with a detailed discussion of practical issues arising in clinical trial optimization and R software implementation (relevant statistical methodology will be moved to the appendix).

Recenzje

"The book Clinical Trial Optimization Using R by A. Dmitrienko and E. Pulkstenis gives a comprehensible introduction to the subject of Clinical Scenario Evaluation (CSE) and subsequent optimization . . . The authors present an approach that is easy to understand and to implement in R. The book is well structured, and the underlying principles are described in detail and illustrated by several case studies."
~ Kiana Kreitz, Institute of Biostatistics and Clinical Research, Germany

Spis treści

Introduction to Clinical Scenario Evaluation. Clinical Scenario Evaluation and Clinical Trial Optimization. General Clinical Trials Settings. Clinical Trials with Multiple Objectives. Clinical Trials with Adaptive Designs. Subgroup Analysis in Clinical Trials. Dose-Finding Clinical Trials. Bayesian Approaches in Clinical Trials