Clinical Laboratory Animal Medicine: An Introduction

ISBN-13: 9781119489566 / Angielski / Miękka / 2019 / 512 str.

Lesley A. Colby; Megan H. Nowland; Lucy H. Kennedy

Spis treści

About the Authors xiiPreface xiiiAbout the Companion Website xiv1 Introduction to Laboratory Animal Medicine 1Animals Used in Research, Teaching, and Testing 2Ethical Considerations 8Organizations 12Bibliography 17Further Reading 18Chapter 1 Review 192 Regulations, Policies, and Principles Governing the Care and Use of Laboratory Animals 22Animal Welfare Act and Regulations 22Public Health Service Policy on Humane Care and Use of Laboratory Animals 28Other Regulations, Policies, Guidance Documents, and Organizations 31References 36Further Reading 37Chapter 2 Review 373 Facility Design, Housing, Equipment, and Management 39Laboratory Animal Facility Design 39Common Facility Classifications 46Housing 50Facility Equipment 59Management 66Bibliography 69Further Reading 69Chapter 3 Review 714 Mice 74Genetics 74Microbiologic Classifications 76Uses 77Behavior 77Anatomic and Physiologic Features 78Breeding and Reproduction 80Husbandry 81Techniques 86Special Techniques: Transgenic Production Technology 96Therapeutic Agents 101Introduction to Diseases of Mice 101Viral Diseases 107References 114Further Reading 119Chapter 4 Review 1225 Rats 124Genetics 124Microbiologic Classifications 125Uses 126Behavior 126Anatomic and Physiologic Features 127Breeding and Reproduction 129Husbandry 130Techniques 133Therapeutic Agents 143Introduction to Diseases of Rats 144Bibliography 157Further Reading 162Chapter 5 Review 1626 Gerbils 165Uses 165Behavior 166Anatomic and Physiologic Features 166Breeding and Reproduction 167Husbandry 168Techniques 170Therapeutic Agents 176Introduction to Diseases of Gerbils 176Bibliography 181Further Reading 183Chapter 6 Review 1847 Hamsters 185Uses 185Behavior 186Anatomic and Physiologic Features 187Breeding and Reproduction 189Husbandry 190Techniques 192Therapeutic Agents 198Introduction to Diseases of Hamsters 198Bibliography 207Further Reading 209Chapter 7 Review 2108 Guinea Pigs 212Uses 212Behavior 213Anatomic and Physiologic Features 214Breeding and Reproduction 216Husbandry 218Techniques 219Therapeutic Agents 225Introduction to Diseases of Guinea Pigs 226Bibliography 238Further Reading 240Chapter 8 Review 2429 Chinchillas 243Uses 243Behavior 244Anatomic and Physiologic Features 244Breeding and Reproduction 246Husbandry 247Techniques 249Therapeutic Agents 253Introduction to Diseases of Chinchillas 255Bibliography 260Further Reading 262Chapter 9 Review 26210 Zebrafish 264Uses 264Behavior 265Anatomic and Physiologic Features 265Reproduction and Life Stages 266Husbandry 268Techniques 274Therapeutic Agents 278Introduction to Diseases of Zebrafish 278Bibliography 283Further Reading 284Chapter 10 Review 28511 Rabbits 286Breeds 286Uses 287Behavior 288Anatomic and Physiologic Features 288Breeding and Reproduction 291Husbandry 293Techniques 297Therapeutic Agents 308Introduction to Diseases of Rabbits 309Bibliography 326Further Reading 329Chapter 11 Review 33112 Ferrets 333Uses 333Behavior 334Anatomic and Physiologic Features 334Breeding and Reproduction 336Husbandry 337Techniques 339Therapeutic Agents 347Introduction to Diseases of Ferrets 347Bibliography 365Further Reading 369Chapter 12 Review 36913 Primates 371Taxonomy 371Uses 375Behavior 376Anatomic and Physiologic Features 377Breeding and Reproduction 378Husbandry 380Techniques 383Therapeutic Agents 390Introduction to Diseases of Nonhuman Primates 390Bibliography 410Further Reading 413Chapter 13 Review 41614 Cattle, Sheep, Goats, and Pigs 417Uses 417Behavior 418Anatomic and Physiologic Features 419Breeding and Reproduction 419Husbandry 420Techniques 424Therapeutic Agents 428Introduction to Diseases of Agricultural Animals of Particular Importance to Research 428Bibliography 434Further Reading 435Chapter 14 Review 43515 Research Variables, Biosecurity, and Colony Health Surveillance 437Research Variables 437Biosecurity and Exclusion of Contaminants 445Animal Colony Health Surveillance 448Bibliography 455Further Reading 455Chapter 15 Review 456Appendix 1: Normal Values 459Appendix 2: Comparative Biologic and Reproductive Values by Species 464Answers to Review Questions 467Index 474

O autorze

The authorsLesley A. Colby, DVM, MS, DACLAM, is an Associate Professor and Senior Director of Animal Resources and Operations in the Department of Comparative Medicine at the University of Washington in Seattle, Washington, USA.Megan H. Nowland, DVM, DACLAM, is an Associate Professor in the Unit for Laboratory Animal Medicine at the University of Michigan in Ann Arbor, Michigan, USA.Lucy H. Kennedy, DVM, DACLAM, is an Assistant Professor in the Unit for Laboratory Animal Medicine at the University of Michigan in Ann Arbor, Michigan, USA.