Clinical Epidemiology: Practice and Methods

ISBN-13: 9781071611371 / Angielski / Twarda / 2021 / 650 str.

Patrick S. Parfrey; Brendan J. Barrett

Spis treści

Preface…

Table of Contents…

Contributing Authors…

 

Part I Introduction

 

1.   On Framing the Research Question and Choosing the Appropriate Research Design

Patrick S. Parfrey and Pietro Ravani

 

2.   Bias in Clinical Research

Susan Stuckless and Patrick S. Parfrey

 

3.   Definitions of Bias in Clinical Research

Geoffrey Warden

 

4.   Research Ethics for Clinical Researchers

John D. Harnett

 

       5.  Ethical, Legal, and Social Issues (ELSI) in Clinical Genetics Research

Daryl Pullman and Holly Etchegary

 

Part II Longitudinal Studies

6.   Longitudinal Studies 1: Determinants of Risk

Sean W. Murphy

 

7.   Longitudinal Studies 2: Modeling Data using Multivariate Analysis

Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey

 

8.   Longitudinal Studies 3: Data Modeling using Standard Regression Models and Extensions

Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey

 

9.   Longitudinal Studies 4: Matching Strategies to Evaluate Risk

Matthew T. James

 

10. Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease

Navdeep Tangri and Claudio Rigatto

  

Part III Randomized Controlled Trials

 

11. Randomized Controlled Trials 1: Design

Bryan M. Curtis, Brendan J. Barrett, and Patrick S. Parfrey

 

12. Randomized Controlled Trials 2: Analysis 

Robert N. Foley and Patrick S. Parfrey

 

13. Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes 

Michelle M. Richardson and Klemens B. Meyer

 

14. Randomized Controlled Trials 4: Planning, Analysis, and Interpretation of Quality of Life Studies

Robert N. Foley and Patrick S. Parfrey

 

15. Randomized Controlled Trials 5: Biomarkers and Surrogates/Outcomes

Claudio Rigatto and Brendan J. Barrett

 

16. Randomized Controlled Trials 6: Determining the Sample Size and Power for Clinical Trials and Cohort Studies

Tom Greene

 

17. Randomized Controlled Trials 7: On Contamination and Estimating the Actual Treatment Effect

      Patrick S. Parfrey

 

 Part IV Other Clinical Epidemiology Methods

 

18. Evaluation of Diagnostic Tests

Brendan J. Barrett and John M. Fardy

 

19. Genetic Epidemiology of Complex Phenotypes

Darren D. O’Rielly and Proton Rahman

20. Qualitative Research in Clinical Epidemiology

Stephanie Thompson and Kara Schick-Makaroff 

  

Part V Methods in Evidence-Based Decision Making

 

21. Evidence Based Decision Making 1: Critical Appraisal 

Laurie K. Twells

22. Evidence Based Decision Making 2: Systematic Review and Meta-Analysis 

Aminu Bello, Ben Vandermeer, Natasha Wiebe, Amit X. Garg, and Marcello Tonelli

23. Evidence-Based Decision Making 3: Health Technology Assessment

Daria O’Reilly, Richard Audas, Kaitryn Campbell, Meredith Vanstone, James M. Bowen, Lisa Schwartz, Nazila Assasi, and Ron Goeree

 

24. Evidence-Based Decision Making 4: Clinical Practice Guidelines

      Tae Won Yi, Sine Donnellan, and Adeera Levin

 

25. Evidence-Based Decision Making 5: Knowledge Translation and the Knowledge to Action Cycle

Braden J. Manns

 

26. Evidence-Based Decision Making 6: Administrative Databases as Secondary Data Source for Epidemiologic and Health Service Research

Tanvir Turin Chowdhury and Brenda R. Hemmelgarn

 

27. Methods in Evidence-Based Decision Making 7: Health Economics in Clinical Research

Braden J. Manns 

 

28. Methods in Evidence-Based Decision Making 8: A Primer for Researchers

      Victor Maddalena and Maisam Najafizada 

 

 Part VI Changing Health-Related Behaviors

 

29. Changing Health-Related Behaviors 1: Patient-Oriented Research and Patient Engagement in Health Research

Catherine Street, Laurie K. Twells, Toni Leamon, Lynn Taylor, and Holly Etchegary

 

30. Changing Health-Care Behaviors 2: On Improving the Value of Health Spending

Karen Dickson, Robert Wilson, Owen Parfrey, and Patrick S. Parfrey

 

31. Changing Health-Related Behaviors 3: Lessons from Implementation Science

Amanda Hall, Helen Richmond, Krista Mahoney, and James Matthews

 

32. Changing Health-Related Behaviors 4: Realizing Impact of Health Research through Knowledge Translation

Kate Lambert, Krista Mahoney, and Patrick S Parfrey

 

33. Changing Health-Related Behaviors 5: On Interventions to Change Physician Behaviors

Cheryl Etchegary, Lynn Taylor, Krista Mahoney, Owen Parfrey, and Amanda Hall

 

34. Changing Health-Related Behaviors 6: Analysis, Interpretation, and Application of Big Data

Randy Giffen and Donald Bryant

 

 

Subject Index List…

Blurb

This third edition volume expands on the previous editions with updated chapters on longitudinal studies, randomized trials, evidence-based decisions making, and a new section on changing health-related behaviors. The chapters in this book are organized into six parts: Part One focuses on framing clinical research questions and choosing a suitable design; biases that may occur in clinical research; and the ethics associated with doing conducting research on humans. Parts Two through Four discuss designs, measurements, and analysis that pertain to evaluation of risk in longitudinal studies; assessment of therapy in controlled trials; and evaluation of diagnostic tests. Part Five presents methods used in various components of evidence-based decision-making; and Part Six highlights interventions focused on changing health-related behaviors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of various types of bias, step-by-step, readily reproducible protocols for different research designs, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Clinical Epidemiology: Methods and Protocols, Third Edition is a valuable resource for clinicians and researchers who want to expand their works to humans and use their findings in the health system.