Clinical Cancer Genomic Medicine: Translational and Applied

ISBN-13: 9780443153211 / Angielski / Miękka / 2026 / 700 str.

Claire Morgan (Associate Professor of Cancer Genetics, MSc Genomic Medicine Programme Director, BSc Medical Genetics/Gen

Opis

Clinical Cancer Genomic Medicine: Translational and Applied covers all major aspects of genetics and genomic of cancer development, diagnosis, and management and the use of them in the clinical setting. It aims to provide readers with not only the genetic basis of cancer, but the role genomics play in understanding the molecular basis of the disease along with aiding diagnosis and treatment.The content is split into three parts: the first, Fundamentals of Cancer Genetics and Genomics, discusses the basics of oncogenomic and emerging technologies; the second, Clinical Cancer Genetics and Genomics, brings information on specific cancer types, such as breast, gastrointestinal, ocular, skin and pediatric; and the third, Clinical Cancer Genomic Medicine, encompasses knowledge on diagnostic cancer genomic techniques, surgical approaches, and ethical, legal, and social implications of cancer genomic testing.It is a valuable resource for oncologists, clinicians, researchers, healthcare workers and members of biomedical field who needs to understand more about the benefits of genetics and genomics for cancer and their application in clinical setting.

Spis treści

Section I: Fundamentals of Cancer genetics and genomics 1. The human genome- organisation & function 2. Introduction to cancer genetics 3. Oncogenes and tumour suppressor genes 4. Cancer epigenomics 5. Cancer and the microbiome- the Oncobiome 6. Cancer immunogenomics 7. Cancer pharmacogenomics 8. Genomic Technologies for Tumour Profiling 9. New emerging technologies- The liquid biopsy 10. Gene and genome editing 11. Bioinformatics for Cancer Genome Analysis Section II: Clinical cancer genetics and genomics 1. Classification and epidemiology of the genetic and inherited cancer- hereditary cancer family syndromes 2. Breast and ovarian cancer including endometrial cancer 3. Gastrointestinal malignancies- oesophagus, colo-rectal, heapto-biliary and pancreatic 4. Central nervous system tumours 5. Neoplasia of endocrine system (Solitary and multiple) 6. Ocular tumours- retinoblastoma 7. Hematological cancer and lympho-reticular malignancy 8. Oro-pharyngeal and lung cancers 9. Malignant melanoma and related skin neoplasia 10. Childhood tumours and paediatric malignant neoplasia disorders 11. Malformation syndromes with neoplasia Section III: Clinical cancer genomic medicine 1. Integration of cancer genomics in clinical medicine 2. Cancer genetic counselling 3. Diagnostic cancer genomic laboratory- organization & function/ cancer database 4. Targeted therapy and screening in cancer genomic / precision medicine 5. Surgical approaches in clinical cancer genetics and genomics 6. Ethical, Legal and Social Implications of cancer genomic testing 7. The future of cancer in the context of the genomics era