Clinical Autonomic and Mitochondrial Disorders: Diagnosis, Prevention, and Treatment for Mind-Body Wellness

ISBN-13: 9783030170189 / Angielski / Miękka / 2020 / 614 str.

Nicholas L. DePace; Joseph Colombo

Spis treści

TABLE OF CONTENTS

DISCLAIMER 6

FOREWORD 7

PREFACE 8

SUMMARY 10

1. INTRODUCTION 17

2. ABOUT THE PROGRAM 18

Energy Production 21

Back To The Program 32

The Importance of Antioxidants 33

3. OMEGA-3 FATTY ACIDS (Prong-1) 47

Details of Oxidized LDL and Atherosclerosis Production 51

Fish Oil Omega-3s as an Anti-inflammatory 54

More Properties of Fish Oil 66

Summary of Cumulative Data 70

4. NITRIC OXIDE (Prong-2) 75

The “Universal Messenger” 77

Detoxification and the Urea Cycle 89

Nitric Oxide Production 92

Beet Root Powder 99

L-Arginine 100

L-Citrulline 105

L-Carnitine 109

The Anti-Atherosclerotic Molecule 110

An Anti-Inflammatory Molecule 113

Erectile Dysfunction 115

An Antioxidant Molecule 116

Heart Failure 117

Nitric Oxide in the Nervous System 124

The Dark-Side of Nitric Oxide 129

Summary 133

5. OXIDATIVE STRESS REDUCTION (Prong-3) 138

Reduce Mitochondrial Dysfunction 142

Oxidative Stress 150

Markers of Oxidative Stress 153

Aldehydes:  Oxidative stress and ROS production vs. Alpha-Lipoic Acid, as Modeled in Diabetes 155

Oxidative Stress in Cardiovascular Diseases 159

Oxidative Stress I:  Biology and Cardiovascular Disease 168

Oxidative Stress II:  Impact on the Heart and Vasculature 170

Oxidative Stress III:  Cardiovascular Risk of Obesity, Diabetes, Smoking, and Pollution 175

Oxidative Stress and Aging 176

Homocysteine 186

Folic Acid (Vitamin B9) 191

Tryptophan 192

Oxidative Stress and Autonomic Neuropathy, Type II Diabetes as a Model 196

Application in Bipolar Disease 221

Application in Heart Failure 223

Application in Fatty Liver Disease 226

Application in Mast Cell Activation Syndrome and Food Allergies 228

Preventing the Dark-Side of Nitric Oxide 232

6. MEDITERRANEAN DIET (Prong-4) 236

Disease and the Mediterranean Diet 239

Endothelial Function and the Mediterranean Diet 247

Polyphenols and the Mediterranean Diet 249

The Mediterranean Diet: What To Expect 250

Health Benefits of Olive Oil 253

The Power of the Grape 256

The Incredible Whole Wheat Grain 258

Resveratrol 262

Antioxidant Effects 263

Mediterranean Diet Summary 266

Alcohol Consumption 273

7. EXERCISE (Prong-5) 276

Exercise and the Nervous System 281

Antioxidant Effects 286

Exercise and Endothelial Function 288

Exercise and Physical Activity 292

8. PSYCHOSOCIAL STRESS REDUCTION (PRONG-6) 305

Hypothalamus-Pituitary-Adrenal Axis Connects Brain and Body 307

The Nervous System’s Brain-Body Connections 314

Modulation of Parasympathetic and Sympathetic Input to the Heart 318

Emotion and Sudden Arrhythmic Death 322

Emotions Modulate P&S Activity 327

Stress, Emotions, The Vagus Nerve, and Inflammation 330

Lateralization of Emotions and P&S Responses 331

The Brain-Heart Connection 334

Dentistry is Also Connected 337

The Vagus Nerve 339

The Brain-Gut Connection 344

Dynamic Parasympathetic Excess 345

Some Comments on Adrenal Fatigue 349

Reducing Stress is an Antioxidant 350

9. Mind-body wellness program benefits 357

Contra-Indications or Interactions 357

Alpha-Lipoic Acid Interactions 357

Coenzyme Q-10 Interactions 358

L-Arginine Interactions 358

L-Carnitine Interactions 358

L-Citrulline Interactions 359

Beet Root Extract (Nitric Oxide Supplement) Interactions 359

Lysine Interactions 359

Folic Acid Interactions 359

Omega-3, Fish Oil Interactions 359

Pharmacology and “Functional Medicine” are Complimentary 360

Cannabidiol (Marijuana) 361

B-Vitamins 362

Questionnaires 364

Compass 31 Questionnaire 366

SF-36 Questionnaire 370

Nottingham Health Profile 377

Simplified Autonomic Questionnaire 379

Questionnaire on Hypermobility Syndromes (EDS and Related Disorders) 380

Dysautonomia Drugs Taken In Past Or Present 383

Composite Autonomic Scoring Scale (CASS) 384

Autonomic Neuropathy Scoring 385

Supplements and Nutraceuticals Help to Improve Pharmacology 386

Antioxidant Treatment and Atrial Fibrillation 388

Anxiety 389

Anxiety and Depression 394

Neurofeedback 399

Atherosclerosis 401

Autonomic Dysfunction and Small Fiber Neuropathy and Their Measurements 401

Breast Cancer, Oxidative Stress, and Cardiovascular Disease 419

Chronic Fatigue Syndrome 420

Persistent Fatigue 423

Congestive Heart Failure 427

Fibromyalgia 428

Hypertension 430

Hypertension Secondary to Parasympathetic Excess 430

Hypertension Secondary to Orthostatic Dysfunction 432

Migraine Headaches 433

Mitochondrial Dysfunction and Neurodegenerative Disorders 436

Post-Traumatic Stress Disorder 449

Telomere Length, Longevity, Fish oils, and Antioxidants 455

Summation 460

Frequently Asked Questions 461

The P&S (Autonomic) Nervous Systems 461

Dysfunction of the P&S Nervous Systems 465

Tests of the P&S Nervous Systems and for Autonomic (P&S) Dysfunction 469

Lightheadedness (“Dizziness”) Due to Autonomic Dysfunction 472

Diseases that Result from Dysfunction of the P&S (Autonomic) Nervous Systems 482

Mitochondria and Mitochondrial Disorders 488

REFERENCES 491

O autorze

Nicholas L. DePace, MD, FACC

Franklin Cardiovascular Associates

Autonomic Dysfunction and POTS Center

Clinical Professor of Medicine

Hahnemann Hospital

Drexel University

Attending Cardiologist 

Pennsylvania Hospital – Penn Medicine

Philadelphia, PA

USA

Joseph Colombo, Ph.D.

CTO & Senior Medical Director, TMCAMS, Inc.

Parasympathetic & Sympathetic Nervous System Consultant

Franklin Cardiovascular Associates

Philadelphia, PA

USA

Blurb

This book establishes and specifies a rigorously scientific and clinically valid basis for nonpharmaceutical approaches to many common diseases and disorders found in clinical settings. It includes lifestyle and supplement recommendations for beginning and maintaining autonomic nervous system and mitochondrial health and wellness. The book is organized around a six-pronged mind-body wellness program and contains a series of clinical applications and frequently asked questions. The physiologic need and clinical benefit and synergism of all six aspects working together are detailed, including the underlying biochemistry, with exhaustive references to statistically significant and clinically relevant studies. The book covers a range of clinical disorders, including anxiety, arrhythmia, atherosclerosis, bipolar disease, dementia, depression, fatigue, fibromyalgia, heart diseases, hypertension, mast cell disorder, migraine, and PTSD. Clinical Autonomic and Mitochondrial Disorders: Diagnosis, Prevention, and Treatment for Mind-Body Wellness is an essential resource for physicians, residents, fellows, medical students, and researchers in cardiology, primary care, neurology, endocrinology, psychiatry, and integrative and functional medicine.  It provides therapy options to the indications and diagnoses published in our book Clinical Autonomic Dysfunction (Springer, 2014).