Clinical Aspects of Interferons

ISBN-13: 9780898383713 / Angielski / Twarda / 1988 / 366 str.

Michel Revel

Spis treści

I Clinical Uses in Infectious and Immune Diseases.- 1. Intranasal Interferons for Control of Respiratory Viral Infections.- 2. Interferon Therapy of Herpes Simplex Dermal Infections and Papillomavirus Condylomata.- 3. Interferon Therapy in Acute Viral Illnesses.- 4. Kaposi’s Sarcoma and AIDS: The Role of Interferons in Treatment.- 5. Use of Interferon in the Treatment of Subacute Sclerosing Panencephalities.- 6. Multiple Sclerosis: Clincial Trials with Interferons.- 7. The Promise of Interferon Therapy for Parasitic Diseases.- II Clinical Uses in Cancer.- 8. Interferon Treatment of Non-Hodgkin’s Lymphoma and Myeloma: A Model for Biotherapy.- 9. The Role of Interferon Alpha in the Treatment of Hairy Cell Leukemia (HCL).- 10. Clinical Studies of Alpha and Gamma Interferons in Chronic Myelogenous Leukemia.- 11. Interferon Therapy of Chronic Lymphocytic Leukemia and Viral Infections in Leukemia Patients.- 12. Interferons in the Treatment of Metastatic Renal Cell Carcinoma.- 13. Interferons in Breast Cancer.- 14. Osteosarcoma Management and Interferon.- 15. Clinical Use of Interferons in the Treatment of Malignant Brain Tumors.- 16. Interferon Treatment of Neuro-Endocrine Tumors of Pancreas and Gut.- 17. The Role of Beta Interferon in the Treatment of Cervical Dysplasia.- 18. Interferons in Combination with Cytotoxic Modalities for Cancer Treatment.- III Biological Properties and Experimental Systems.- 19. Toxic Effects.- 20. Pharmacokinetics of Interferons and Practical Implications.- 21. Monitoring of Interferon Therapy by Assay of Interferon-Induced (2 ??5?) Oligo A Synthetase in Human Peripheral White Blood Cells.- 22. Interferon Studies in Non-Human Primates.- 23. Animal Model Systems to Evaluate the Antitumor Activity of Interferons.- 24. Effects of Polynucleotides on Monkeys and Man.- 25. Delivery of Interferons to Target Cells by Monoclonal Antibodies: Potential for the Specific Targeting of Other Lymphokines.- 26. Immunomodulatory Actions of Interferons.- 27. Synergistic Actions of Interferons and Tumor Necrosis Factor.