Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols

ISBN-13: 9781071635407 / Angielski

Uttam Garg

Spis treści

1. Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology

            Y. Victoria Zhang and Uttam Garg

 

2. Quantitative LC-MS/MS Analysis of Amphetamines and Cocaine in Human Urine

            Putuma P. Gqamana and Y. Victoria Zhang

 

3. Quantification of Gabapentin, Lacosamide, Perampanel, Pregabalin, Rufinamide, and Vigabatrin in Serum Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

            Eunbin Chong, Hyeonju Oh, Dong Ju Kim, Sang-Mi Kim, and Soo-Youn Lee

 

4. Turbulent Flow Liquid Chromatography-Tandem Mass Spectrometry Methods for Antiepileptic Drug Quantitation in Serum

            Adam S. Ptolemy, Roy W.A. Peake, and Mark D. Kellogg

 

5. Quantitative LC-MS/MS Method for the Simultaneous Measurement of Six Antiepileptics and Pentobarbital in Human Serum

            Geza S. Bodor and Amanda J. Rands

 

6. Triazole Antifungal Quantification for Therapeutic Drug Monitoring in Serum by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS):  Posaconazole, Voriconazole, Itraconazole, and Hydroxyitraconazole

            Mark Girton, Jose Tomsig, and Lindsay Bazydlo

 

7. Liquid Chromatography-Tandem Mass Spectrometry-Based Therapeutic Monitoring of Plasma Atovaquone Concentrations in Pediatric Patients

            Thomas D. Horvath and Sridevi Devaraj

 

8. Analysis of Barbiturates in Urine by LC-MS/MS

            Matthew Campbell, Gregory Janis, Hunter Horne, and Hemamalini Ketha

 

9. High Throughput Quantitative LC-MS/MS Analysis of Barbiturates in Human Urine

            Putuma P. Gqamana and Y. Victoria Zhang

 

10. High Throughput Quantitative LC-MS/MS Analysis of Benzodiazepines in Human Urine

            Putuma P. Gqamana and Y. Victoria Zhang

 

11. Quantitation of Bupropion in Urine by Liquid Chromatography-Tandem Mass Spectrometry

            Xu Li, Natalie Plotkina, and Janetta Bryksin

 

12. Quantitative Analysis of Buprenorphine, Norbuprenorphine, and Their Glucuronide Metabolites in Human Urine

            Putuma P. Gqamana, Daniel Rudy, and Y. Victoria Zhang

 

13. Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantification of Plasma Busulfan

            Uttam Garg, Ada Munar, and C. Clinton Frazee III

 

14. Determination of Busulfan and Melphalan in Plasma by Turbulent Flow Chromatography-Tandem Mass Spectrometry

            Ryan C. Schofield, Michael Scordo, Gunjan Shah, and Dean C. Carlow

 

15. Serum and Urine Quantification of Delta-8 and Delta-9 Tetrahydrocannabinol Carboxylic Acid Using Gas Chromatography-Mass Spectrometry

            Serena Shell, C. Clinton Frazee III, and Uttam Garg

 

16. 11-Nor-9-Carboxy-Δ8-Tetrahydrocannabinol, 7-Carboxy Cannabidiol, and 11-Nor-9-Carboxy-Δ9-Tetrahydrocannabinol in Urine by LC-MS/MS

            Melissa L. Hughs and Gwendolyn A. McMillin

 

17. Quantification of Clofarabine and Fludarabine in Plasma by High Performance Liquid Chromatography-Tandem Mass Spectrometry

            Ryan C. Schofield, Michael Scordo, Gunjan Shah, and Dean C. Carlow

 

18. Untargeted High-Resolution Mass Spectrometry for Detection of Natural Products and Confiscated Powders and Pills

            Erica Beckerdite and Alan H.B. Wu

 

19. Drug Screening of 49 Compounds by Liquid Chromatography-Tandem Mass Spectrometry in Saliva

            Xu Li, Natalie Plotkina, and Janetta Bryksin

 

20. High Throughput Comprehensive Quantitative LC-MS/MS Analysis of a Common Drugs and Metabolites (62 Compounds) in Human Urine

            Putuma P. Gqamana and Y. Victoria Zhang

 

21. Detection of 41 Drugs and Metabolites in Urine with Internal Hydrolysis Control by Liquid Chromatography-Tandem Mass Spectrometry

            Stephen D. Merrigan, Yifei Yang, Gwendolyn A. McMillin, and Jessica M. Boyd

 

22. Comprehensive Urine Drug Screen by Gas Chromatography-Mass Spectrometry (GC-MS)

            Bheemraj Ramoo, C. Clinton Frazee III, and Uttam Garg

 

23. Comprehensive Urine Drug Screen by Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry

            Sarah B. Riley

 

24. A Liquid Chromatography-Tandem Mass Spectrometry Assay for Quantification of Ethyl Glucuronide and Ethyl Sulfate in Urine

            Justin Dowis, Xiang He, Lori Pham, and Deborah French

 

25. Quantification of Fentanyl and Norfentanyl in Whole Blood Using Liquid Chromatography-Tandem Mass Spectrometry

            Serena Shell, C. Clinton Frazee III, and Uttam Garg

 

26. Quantitative Assay of Fentanyl and Analogues Using LC-MS/MS

            Hannah M. Brown and Sarah B. Riley

 

27. Analysis of Hypoglycemic Drugs by Liquid Chromatography-Tandem Mass Spectrometry

            Paul J. Jannetto and Loralie J. Langman

 

28. Multiplex Immunosuppressant (ISD) Method for the Measurement of Cyclosporine A, Tacrolimus, Sirolimus/Rapamycin, and Everolimus in Whole Blood Using MassTrak^TM Kit

            Anqi Zhang and Steven E. Conklin

 

29. Assessment of Iohexol Serum Clearance by LC-MS/MS with Isotopically Labeled Internal Standard

            Zhicheng Jin, Roger L Bertholf, and Xin Yi

 

30. Quantification of Mycophenolic Acid in Plasma by High Performance Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

            Aja Aravamudhan, Cynthia L. Johnson, and Jesse C. Seegmiller

 

31. Quantitation of Urine Nicotine, Cotinine, and 3-OH-Cotinine by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

            Wenbo Li, Xiaochun Susan Zhang, and Jaime Noguez

 

32. Quantification of Olanzapine by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

            Kamisha L. Johnson-Davis and Diane Ly

 

33. Quantitative Opiate, Opioid, and Benzodiazepine Testing by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

            Jacob Rininger, Audrey Black, Wenbo Li, and Jaime Noguez

 

34. Quantitative LC-MS/MS Analysis of Opiates and Opioids in Human Urine

            Putuma P. Gqamana and Y. Victoria Zhang

 

35. Quantification of Oxcarbazepine Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

            Kamisha L. Johnson-Davis and Ronald L. Thomas

 

36. Liquid Chromatography-Tandem Mass Spectrometry for Quantitation of Serum Pentobarbital

            Hafiz Anas Yahya and Patrick B. Kyle

 

37. Quantification of Phencyclidine (PCP) in Urine, Serum, or Plasma by Gas Chromatography-Mass Spectrometry (GC-MS)

            David Scott, C. Clinton Frazee III, and Uttam Garg

 

38. Simultaneous Determination of Prednisone and Prednisolone in Serum by Turbulent Flow Liquid Chromatography-Tandem Mass Spectrometry

            Ryan C. Schofield, Michael Scordo, Gunjan Shah, and Dean C. Carlow

 

39. Measurement of ThioTEPA and Its Metabolite TEPA in Plasma and Cerebrospinal Fluid by Turbulent Flow Chromatography-Tandem Mass Spectrometry

            Ryan C. Schofield, Michael Scordo, Gunjan Shah, and Dean C. Carlow

 

40. A Direct Dilute and Shoot HPLC-MS/MS Method for Tetrahydrocannabinol (THC) Metabolites

            Brandy Young and Y. Victoria Zhang

 

41. Quantification of Thiopurine Metabolites in Human Erythrocytes by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

            Lie Li, Natalya Atkinson, Kristine R. Crews, and Alejandro R. Molinelli

 

42. Determination of Treosulfan and Fludarabine in Plasma by Turbulent Flow Liquid Chromatography-Tandem Mass Spectrometry (TFLC-MS/MS)

            Shelby M. Hutcherson, Ryan C. Schofield, and Dean C. Carlow

 

43. Determination of Thiopurine S-Methyltransferase (TPMT) Activity in Human Erythrocytes by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

            Lie Li, Natalya Atkinson, Kristine R. Crews, and Alejandro R. Molinelli

Blurb

This fully updated volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Exploring the versatility and flexibility of mass spectrometry, the book covers the advantages of this technology, which typically include elimination of the need for special reagents such as antibodies, increased sensitivity and specificity, and multi-component analysis enabling the screening of tens to hundreds of compounds in a single assay run. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. 

Authoritative and up-to-date, Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols, Second Edition serves as a valuable resource for laboratory professionals who are already utilizing mass spectrometry or considering bringing this technology to their labs.