Circadian Rhythms and Their Impact on Aging

ISBN-13: 9783319645421 / Angielski / Twarda / 2017 / 361 str.

S. Michal Jazwinski; Victoria P. Belancio; Steven Hill

Opis

Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.

Spis treści

1-      The yeast metabolic cycle, cell cycle, and lifespan
Benjamin Tu

2-      The Neurospora biological clock and aging
Jonathan Arnold

3-      The circadian clock and aging of Drosophila
Jadwiga Giebultowicz

4-      Mammalian models of circadian biology with emphasis on aging
Marina Antoch

5-      Organization and functional dynamics of circadian clocks in mammalian model systems in relation to aging
Joseph Takahashi

6-      Age-related changes in circadian and nuclear receptor cross talk
David Mangelsdorf

7-      Circadian integration of whole animal mammalian metabolism and energetics
Joseph Bass

8-      Circadian rhythms of metabolism and chromatin remodeling
Paolo Sassone-Corsi

9-      The circadian clock and mTOR
Roman Kondratov

10-  Cell senescence, DDR, SASP and genomic instability
Judy Campisi

11-  Circadian control of DNA repair
Aziz Sancar

12-  Epidemiology of circadian disruption and human health
Richard Stevens

13-  Impact of melatonin – reciprocal relationship with aging
Russ Reiter

14-  Aging and circadian misalignment on inflammation and immune response pathways
Regina Markus

15-     Impact of the circadian system and its misalignment on metabolic and cardiovascular dynamics
Frank Scheer

16-     Detoxification and the circadian system
Anton Jetten

17-     Circadian system and bone metabolism
Paula Witt-Enderby

18-     Circadian sleep-wake regulation during aging
Steven Lockley

19-     Modeling the eukaryotic cell cycle
John Tyson

20-     Circadian system and responses to chronotherapy
William Hrushesky

I

O autorze

S. Michal Jazwinski, Ph.D. is the John W. Deming, M.D. Regents Chair in Aging, Professor of Medicine, and Director of the Tulane Center for Aging at Tulane University.  His research on various aspects of aging has been funded by the National Institute on Aging (NIH) and private foundations, and it spans over thirty years.  It includes genetic studies in model organisms and multidisciplinary studies in humans.

Victoria P. Belancio, Ph.D. is an Associate Professor of Structural and Cellular Biology at Tulane University. Her research on retrotransposon-associated genomic instability has been funded by the National Institute on Aging (NIH) and private foundations. It includes projects investigating how circadian disruption impacts DNA damage induced by retroelements and whether this damage influences mammalian aging.

Steven M. Hill, Ph.D. is the Edmond and Lily Safra Chair for Breast Cancer Research, Professor of Structural & Cellular Biology, and Director of the Tulane Center for Circadian Biology at Tulane University.  His research on various aspects of circadian biology and breast cancer has been funded by the National Cancer Institute (NIH), the Army Department of Defense Breast Cancer Program, and private foundations, and spans over 25 years.   His recent research efforts have focused on the impact of circadian/melatonin disruption by light at night on human breast cancer progression, metastasis, and drug resistance.

Blurb

This book examines the role of circadian rhythms in aging, an emerging area of biology.  Although implicated in aging and longevity for over forty years, the richness of the ways in which the circadian system impacts aging has become evident only more recently.  The circadian system consists of a central pacemaker and a multitude of peripheral clocks, located in most cells throughout the organism. These clocks keep metabolic, physiological, and behavioral patterns in tune with the twenty-four hour day/night cycle and with each other.  Disruptions of the circadian system, such as the presence of light at night, can have profound pathological implications.  The core circadian oscillator consists of a multicomponent transcriptional feedback loop that regulates the periodicity of expression of some ten percent of the genes in the human genome.  This easily explains the broad influence of the circadian system.

 

The chapters in this volume fall into four sections that follow a brief introduction.  They are written by experts performing the research in this field.  The first section/chapter surveys the operation of the aging circadian system with a focus on melatonin signaling.  In the second section, this theme is amplified through a discussion of the aging lung, bone, and gastrointestinal system.  A section composed of eight chapters explores in detail cellular and molecular mechanisms associated with circadian system aging, in a range of experimental models.  The studies reviewed include genetic, epigenetic, molecular, cell biological, metabolic, and physiologic approaches.  The final section details the effects of sleep disruption on mortality risk in older adults and the effects of physical activity on circadian rhythms in the elderly, adding to the earlier discussion of the potential of chronotherapeutics.

 

Advanced undergraduates and graduate students will find this book both a suitable introduction and a definitive treatment of the impact of circadian rhythms on aging.  Instructors and researchers in circadian biology and in aging biology will discover this to be a valuable reference work, which brings these fields into juxtaposition and merger.  This volume will contribute to further advances in this important interdisciplinary area.