Cilia and Mucus: From Development to Respiratory Defense

ISBN-13: 9780824704414 / Angielski / Twarda / 2001 / 450 str.

Matthias Salathe;Salathe

Opis

This book details advances in research regarding cilia, mucus, and mucociliary clearance, examining changes in mucus expression and goblet cell metaplasia, and assessing the ability of the mucociliary system to respond to abnormalities.
Recognizes that cilia and dynein arms play pivotal roles in developing mammalian embryos
Examines the role of genetics in normal and abnormal ciliary function
Discussing scientific fundamentals, current diagnostic techniques, and clinically tested treatments, Cilia and Mucus

analyzes the regulation of ciliary waves at the cellular level

considers irregularities of upper and lower airways and cilia in systems of the body

explores potential modulators of airway mucin secretion

proposes a novel therapy for airway hypersecretion due to the epidermal growth factor cascade

clarifies gamma camera imaging to measure mucociliary clearance

describes the effect of purinergic receptors and dry powder mannitol on airway passages

and more
With contributions from over 100 international researchers and clinicians, and containing over 1300 references, drawings, photographs, tables, and equations, Cilia and Mucus is a unique single-source reference for pulmonologists, physiologists, immunologists, allergists, otolaryngologists, pediatricians, microbiologists, basic scientists, and graduate and medical school students in these disciplines.

Recenzje

"
…a comprehensive and up-to-date review of the topic.
"-Allergy

Spis treści

CILIA

Cytoplasmic Dynein-2 and Ciliogenesis
David J. Asai
Dynein Motor Activity During Ciliary Beating
Michael E. J. Holwill
Ciliary Growth by Intraciliary Trafficking
Dawn Signor, Karen P. Wedaman, Jose T. Orozco, Lesilee S. Rose, and Jonathan M. Scholey
The Regulation of Airway Ciliary Beat Frequency by Intracellular Calcium
Michael J. Sanderson, Alison B. Lansley, and John H. Evans
Modeling the Response of Mammalian Ciliary Beating to Changes in Cytoplasmic Calcium
Matthias Salathe and Richard J. Bookman
Enhancement of CBF Is Dominantly Controlled by PKG and/or PKA
Alex Braiman, Natalya Uzlaner, and Zvi Priel
Modulation of Ciliary Motility by Na+
Shai D. Silberberg, Alon Korngreen, Weiyuan Ma, Natalya Uzlaner, and Zvi Priel
Presentation of Ciliary Beat Frequency Results to Our Peers
X. Mwimbi, R. Muimo, and Anil Mehta
Identifying the Genes for Primary Ciliary Dyskinesia and Kartagener Syndrome
Michal Witt, Ewa Rutkiewicz, Yue-Fen Wang, Cui-e Sun, Diego F. Wyszynski, Scott R. Diehl, Jacek Pawlik, and Jerzy Zebrak
Homozygosity Mapping as an Approach for Identifying Genes Involved in Primary
Ciliary Dyskinesia S. L. Spiden and H. M. Mitchison
Mutations in the Novel Mammalian Gene DNAI1 Result in Primary Ciliary Dyskinesia
Gaëlle Pennarun, Catherine Chapelin, Anne-Marie Bridoux, Valère Cacheux, Michel Goossens, Serge Amselem, Bénédicte Duriez, Estelle Escudier, Gilles Roger, and Annick Clément
Molecular Strategies for the Study of Human Cilia
Lawrence E. Ostrowski
Ciliated Ependymal Cells: The Effect of Streptococcus pneumoniae on the Beat Frequency Response
Robert A. Hirst, T. J. Mitchell, P. W. Andrew, and C. O'Callaghan
The Cytoprotective Effects of Macrolides, Azalides, and Ketolides on Human Ciliated Epithelium In Vitro
Charles Feldman, Ronald Anderson, Annette J. Theron, Peter Cole,and Robert Wilson
Examining Mucociliary Differentiation of Human Nasal Epithelial Cells In Vitro
J. Laoukili, K. Million, O. Houcine, F. Marano, Frédéric Tournier, E. Perret, and D. Caput

MUCUS

Respiratory Tract Mucins
Julia R. Davies and Ingemar Carlstedt
MARCKS Protein: A Potential Modulator of Airway Mucin Secretion
Yuehua Li, Linda D. Martin, and Kenneth B. Adler
Airway Goblet and Mucous Cells: Identical, Similar, or Different?
C. William Davis and Scott H. Randell
Regulation of Respiratory Mucin Gene Expression by Neutrophil Elastase
Judith A. Voynow and Bernard M. Fischer
Pseudomonas Adhesion to MUC1 Mucins: A Potential Role of MUC1 Mucins in Clearance of Inhaled Bacteria
Kwang Chul Kim, Sang Won Hyun, Beom Tae Kim, Daoud Meerzaman, Min Ki Lee, and ErikLillehoj
High-Density DNA Microarray Membranes to Study Gene Expression Patterns Associated with Human Airway Epithelial Cell Differentiation in Culture
Mary M. J. Chang, Yin Chen, Yu Hua Zhao, Reen Wu, Ching Li, and Konan Peck
In Vivo Models of Airway Goblet Cell Hyperplasia and Mucin Gene Expression
Alinka K. Smith and Duncan F. Rogers
Interleukin-13-Induced Mucous Cell Hyperplasia in Airway Epithelium
Linda D. Martin, Brian W. Booth, Nancy J. Akley, Kenneth B. Adler, Mariangela Macchione, and James C. Bonner
Airway Mucins and Lung Cancer
Chong-Jen Yu and Pan-Chyr Yang
Charged Oligosaccharides as Novel Mucolytic Therapies
Malcolm King, Eiichi Sudo, and Martin M. Lee

MUCOCILIARY INTERACTIONS

Modeling Aspects of Tracer Transport in Mucociliary Flows
J. R. Blake and E. A. Gaffney
P2Y2 Receptors and Ca2+-Dependent Cl- Secretion in Normal and Cystic Fibrosis Human Airway Epithelia
Carla M. Pedrosa Ribeiro, Anthony M. Paradiso, Eduardo Lazarowski, and Richard C. Boucher
Role of Epidermal Growth Factor Receptor Cascade in Airway Hypersecretion and Proposal for Novel Therapy
Jay A. Nadel
In Vivo Measurement of Mucociliary Clearance: The Use of Gamma Camera Imaging
Joy Conway
Regulation of Mucociliary Clearance by Purinergic Receptors
William D. Bennett, Peadar G. Noone, Michael Knowles, and Richard C. Boucher
The Effect of Dry Powder Mannitol on the Clearance of Mucus
Evangelia Daviskas, Michael Robinson, Sandra D. Anderson, and Peter T. P. Bye
Neutrophil Elastase and Antigen-Induced Mucociliary Dysfunction
Thomas O'Riordan and William M. Abraham
Mechanisms of Clearance of Soluble Substances from the Intrathoracic Airways
W. Michael Foster and Elizabeth M. Wagner
The Role of Cough in Lung Mucus Clearance
Amir Hasani and John E. Agnew
Cough Clearance of Mucus Simulants in Endotracheal Tubes: Patterns of Catastrophic Separation at Controlled Linear Velocities
Peter Krumpe, Bruce Denney, Amgad Hassan,Ross Albright, and Cahit Evrensel

O autorze

Matthias Salathe