Chronic Lymphocytic Leukemia: Pathobiology, B Cell Receptors, Novel Mutations, Clonal Evolution

ISBN-13: 9783319706023 / Angielski / Twarda / 2018 / 135 str.

Prabhjot Kaur

Opis

This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for pathologists and clinical hematologists/oncologists with an interest in chronic lymphocytic leukemia.

Spis treści

Definition, Epidemiology, Monoclonal B cell lymphocytosis, Morphology , Immunophenotype, Transformation, Gene expression profiling.- Chromosomal aberrations in CLL :Karyotype and FISH.- B cell receptors (BCRs).- Novel mutations in CLL.- Clonal evolution and the Driver/Passenger Mutation Model in CLL.- Prognosis and predictive factors - Hierarchal classification.- MiRNAs.

O autorze

Dr Prabhjot Kaur, is currently an Associate Professor of Pathology, Director , Hematology Laboratory at the Department of Pathology, Dartmouth Hitchcock Medical Center and

Geisel School of Medicine at Dartmouth. She initially trained in India with further residency training in anatomic and clinical pathology at the Albany Medical Center, Albany, NY and at the Mayo Clinic, Rochester MN. She has been practicing pathology as faculty for the past 12 years. Her interest beyond pathology include oil/impasto style and acrylic paintings that have been exhibited locally in New Hampshire and also published in an international anthology of art and poetry. She is a mother of two smart millennials who provide several opportunities to learn and live.   

Prabhjot Kaur, MD

Associate Professor of Pathology

Department of Pathology

Dartmouth Hitchcock Medical Center and

Geisel School of Medicine at Dartmouth

Lebanon, NH 

Blurb

This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for pathologists and clinical hematologists/oncologists with an interest in chronic lymphocytic leukemia. This book is designed to provide a concise yet comprehensive summary of the traditional and new definitions, prognostic markers, the pathobiology and newer hierarchal classification based on molecular genetics/chromosomal abnormalities.  It will include the most up-to-date scientific and clinical information and bring together subject matter that is usually covered separately in various specialties of hematopathology, molecular pathology, basic science and immunology. The book is written in an easy to comprehend format with emphasis on the science and illustrations to explain the same. It is therefore intended to intrigue, the junior resident and the senior pathologists/clinical oncologists and anyone who would like to keep up with this rapidly growing field.