Chronic Lymphocytic Leukemia

ISBN-13: 9781420068955 / Angielski / Twarda / 2008 / 312 str.

Susan O'Brien; John G. Gribben

Opis

Written by authors from the world s most prominent cancer centers, Chronic Lymphocytic Leukemia supplies a comprehensive, up-to-date picture of CLL and how to better treat patients inflicted with the disease. New information on developments in the molecular pathogenesis of this disease impacts how physicians approach and treat patients with CLL. The various predisposing factors for the disease are addressed along with current and future treatment modalities and recommended standards of care. Key features include:

• introduction by Kanti Rai, MD who developed the Rai Classification and Staging system used in CLL diagnosis
• CLL in relationship to gene expression profiling and molecular abnormalities
• familial clustering and gene predisposition
• targeted therapy trials
• clinical patient management based upon stage and progression of disease

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Spis treści

1. Origin and Nature of the CLL Cell. 2. Gene Expression Profiling. 3. Molecular Pathogenesis. 4. CLL and the B Cell Receptor. 5. Epidemiology and Familial CLL. 6. Apoptosis Disregulation in CLL. 7. Differential Diagnosis, Staging, and Prognostic Factors. 8. Frontline Therapy. 9. Treatment of Relapsed Disease. 10. New Therapies. 11. Transplant in CLL. 12. Gene therapy, vaccines and immune modulation. 13. PLL. 14. CLL Specific Complications: Autoimmunity and Richter’s Syndrome. 15. Infections in CLL.