Chronic Complications in Diabetes: Animal Models and Chronic Complications

ISBN-13: 9789057024337 / Angielski / Twarda / 2000 / 288 str.

Anders A. F. Sima; Sima A. F. Sima

Opis

Individual volumes in the series Frontiers in Animal Diabetes Research provide basic researchers as well as clinical investigators with in-depth coverage of basic experimental diabetes research. Each volume will be topic oriented with timely and liberally referenced reviews. The series will provide a valuable reference source for basic researchers as well as clinical investigators, graduate students and research fellows in the areas of diabetology, endocrinology, physiology, and pharmacology. Major advances have been made in diabetes research, partly as a result of experimentation in animal models. Experimental animal research has contributed significantly to the understanding of the aetiology of this disease and its dreaded complications. In particular the areas of immunology, insulin signal transduction, and the pathogenetic mechanisms involved in the chronic complications have become clearer. Various animal models used in diabetes research are reviewed, together with the diverse but often interrelated mechanism in the complication of diabetes. The functional and structural consequences in the various target organs are also discussed. Students, trainees, fellows, as well as clinicians and investigators interested in diabetes and its complications will find this new book series a valuable reference source.

Spis treści

1. Diabetic Animals for Research into the Complications - A General Overview 2. Studies in Animal Models on the Role of Glycation and Advanced Glycation End-products (AGE's) in the Pathogenesis of Diabetic Complications: Pitfalls and Limitations 3. Utility of the Transgenetic Mouse in Diabetes Research 4. Oxidative Stress and Abnormal Lipid Metabolism in Diabetic Complications 5. Diabetic Neuropathy in Various Animal Models 6. Neurotrophism in Diabetic Neuropathy 7. Evidence for Altered Calcium Signalling in Excitable Tissues 8. Experimental Diabetic Nephropathy 9. Diabetic Retinopathy in Experimental Animal Models and Their Feasibility for Understanding the Human Disease 10. Fetal Malformations in Diabetes

O autorze

Wayne State University