Chromosome 12 Aberrations in Human Solid Tumors: Cytogenetics and Molecular Genetics

ISBN-13: 9783662062579 / Angielski / Miękka / 2013 / 194 str.

Jorn Bullerdiek; Sabine Bartnitzke; H. Van Den Berghe

Opis

Researchers involved in the cytogenetics and molecular genetics of human tumors will welcome this comprehensive overview of the type of aberrations that chromosome 12 presents in human solid tumors. The authors study the implications for a cytogenetic subtyping of the tumors involved and strategies for identifying the molecular changes which underlie the karyotypic alterations. The aberrations of chromosome 12 which the book deals with are very frequent chromosomal alterations in human tumors occuring in frequent benign mesenchymal tumors, such as uterine leiomyomas and lipomas, and in tumors of epithelial origin, such as pleomorphic adenomas of the salivary glands.

Spis treści

Cytogenetic Background.- Specificity and Implications of Chromosome 12 Abnormalities in Pleomorphic Adenomas.- Involvement of Chromosome 12 in Uterine Leiomyoma.- Lipoma Cytogenetics.- Involvement of Chromosome 12 in Well-Differentiated Liposarcoma.- Breakpoints and Recipient Chromosomes in Pleomorphic Adenomas, Lipomas, and Uterine Leiomyomas — What Do They Tell Us?.- Trisomy 12 Clusters to Tumors of the Female Genital Tract.- Numerical Chromosome 12 Analysis of Carcinoma In Situ and Invasive Germ Cell Tumors of the Adult Testis: A Study Based on the Simultaneous Application of Interphase Cytogenetics and Immunohistochemistry on Tissue Sections.- Cytogenetic and Molecular Studies of Clear-Cell Sarcoma of Tendons and Aponeuroses.- The Molecular Genetics of Chromosome 12.- Comparative Gene Mapping: Human Chromosome 12 and Mouse Chromosome 15.- The Molecular Oncology of 12q13–15.- Gene Analysis: Methods and Facts.- Cell Lines from Tumors Showing 12q13–15 Aberrations.- Analysis of DNA from a Specific Chromosome Region.- Chromosome 12 Aberrations in Human Germ Cell Tumors: A Fluorescence In Situ Hybridization Inventory.- Development and Characterization of Cell Lines from a Myxoid Liposarcoma with t(12;16)(q13;p11.2) and Trisomy 8.- Amplification of the GLI and LRP/A2MR Loci in Tumor Cells: Is GLI only by Chance Coamplified Together with Another Gene Related to Tumor Progression?.- Analysis of Solid Tumours with Recurrent Breakpoints in Chromosome Region 12q13–15 by Fluorescence In Situ Hybridization Using a Microclone Library.- Isolation and Characterisation of NotI-end Cosmids Mapping to Human Chromosome 12p.