Chromosomal Aberrations: Basic and Applied Aspects

ISBN-13: 9783642756849 / Angielski / Miękka / 2011 / 319 str.

G. Nter Obe; A. T. Natarajan

Opis

Chromosomale Mutationen sind eine der m-glichen Ursachen f}r Ver{nderungen der Erbinformation. Neben grunds{tzlichen As- pekten, wie Reparaturmechanismen der Zelle oder Ursachen von Chromosomenver{nderungen, werden angewandte Aspekte, z.B. Chromosomen als Testindikatoren der Toxizit{t, behandelt.

Spis treści

Quantitative Detection of Chromosome Structures by Computerized Microphotometric Scanning.- Heterogeneity of DNA Repair in Relation to Chromatin Structure.- The Poly-ADP-Ribosylation System of Higher Eukaryotes: How Can It Do What?.- DNA Lesions, DNA Repair, and Chromosomal Aberrations.- Is It Misrepair or Lack of Repair Which Kills Cells Irradiated in G2?.- Inhibitors of DNA Topoisomerases and Chromosome Aberrations.- Restriction Endonuclease- and Radiation-Induced DNA Double-Strand Breaks and Chromosomal Aberrations: Similarities and Differences.- The Use of Restriction Endonucleases to Study the Mechanisms of Chromosome Damage.- Induction of Chromosomal Aberrations by the Restriction Endonuclease Alul in Chinese Hamster Ovary (CHO) Cells: Influence of Glycerol on Aberration Frequencies.- Patterns of Chromosome Variations in Neoplasia.- Tumorigenesis and Tumor Response: View from the (Prematurely Condensed) Chromosomes.- Detection of Cancer-Prone Individuals Using Cytogenetic Response to X-Rays.- Human Disorders with Increased Spontaneous and Induced Chromosomal Instability.- Possible Causes of Variability of the Adaptive Response in Human Lymphocytes.- Adaptation of Human Lymphocytes to Radiation or Chemical Mutagens: Differences in Cytogenetic Repair.- Radio-Adaptive Response: A Novel Chromosomal Response in Chinese Hamster Cells in Vitro.- On Adaptive Response of Plant Meristem Cells in Vivo — Protection Against Induction of Chromatid Aberrations.- Chromosome Aberrations in A-Bomb Survivors, Hirsohima and Nagasaki.- Biological Dosimetry of Absorbed Radiation Dose: Considerations of Low-Level Radiations.- Use of Micronuclei in Biological Dosimetry of Absorbed Radiation Dose.- Biological Dosimetry After Radiation Accidents.- Dose Estimates and the Fate of Chromosomal Aberrations in Cesium-137 Exposed Individuals in the Goiania Radiation Accident.- Cytogenetic Studies in Male Germ Cells, Their Relevance for the Prediction of Heritable Effects and Their Role in Screening Protocols.- Use of in Vivo Micronucleus Tests with Mammalian Cells for Clastogenicity and Carcinogenicity Studies.- In Vitro Chromosomal Aberration Test — Current Status.- Clastogenesis in Vitro Under Extreme Culture Conditions.- Life-Style and Genetic Factors that Determine the Susceptibility to the Production of Chromosome Damage.