Chirality in Natural and Applied Science

ISBN-13: 9780849324345 / Angielski / Twarda / 2002 / 336 str.

W. J. Lough; I. W. Wainer; William J. Bennett

Opis

An understanding of chirality is central to the study and application of the molecular sciences. Particularly relevant to the work of pharmaceutical, natural product, organic, and analytical chemists, biochemists, and molecular biologists, Chirality in Natural and Applied Science provides a highly practical overview of the chemical significance of chirality.
Contributions from world-class scientists describe our current understanding of chirality and discuss its significant impact on modern chemistry and molecular science. They explore the origins of chirality, its natural occurrence on a variety of scales, and its current and potential applications in research and industry.
Chirality undoubtedly will remain integral to all of molecular science, and as our knowledge and understanding grow, its importance certainly will increase. Bringing together the insights and experience of scientists who have played influential roles in chirality research, Chirality in Natural and Applied Science helps ensure a thorough understanding of chirality, its importance and its applications.

Spis treści

INTRODUCTION-RETOURNONS À PASTEUR! K. Mislow, Princeton University, USAPASTEUR ON MOLECULAR HANDEDNESS-AND THE SEQUEL, S.F. Mason, Kings College, London, UKPasteur's Optical ResolutionsThe Chemical-Physics Background to Pasteur's 1848 DiscoveryMolecular Structure Theory and Stereoselective Chiral SynthesisChance, Necessity, and Chiral Fields in the Evolution of Biomolecular HomochiralityParity and its Non-ConservationTHE ORIGIN OF BIOMOLECULAR CHIRALITY, A.J. MacDermott, University of Cambridge, UKIntroductionHomochirality-A Hallmark of LifeHomochirality-Also a Pre-Condition for Life?The Need for a Chiral InfluenceFalse Chirality-Magnetic FieldsTrue Chirality-Circularly Polarized PhotonsTrue Chirality-The w BosonTrue Chirality-The z BosonAmplification MechanismsPVEDS of BiomoleculesSo was it Really the Weak Force?Look in Space!Is the Universe Intrinsically Handed?CHIRALITY AT THE SUB-MOLECULAR LEVEL: TRUE AND FALSE CHIRALITY, L.D. Barron, University of Glasgow, UKIntroductionSymmetry PrinciplesTrue ChiralityAbsolute Asymmetric SynthesisChirality and Symmetry ViolationThe Mixed-Parity States of a Chiral MoleculeChirality and RelativityChirality in Two DimensionsConcluding RemarksTHE MOLECULAR BASIS OF CHIRAL RECOGNITION, J. Greer and I.W. Wainer, Abbott Laboratories, Illinois, USA and NIH, Maryland, USAIntroductionKinetic and Thermodynamic Aspects of Enzymatic EnantioselectivityMolecular Chiral Recognition MechanismsThe N-Dechloroethylation of Ifosfamide EnantiomersInteraction of Peptides and Larger Molecules with Chiral BiopolymersConcluding RemarksCHIRALITY IN DRUG DESIGN AND DEVELOPMENT. D.J. Triggle, University of New York at Buffalo, USAIntroductionThe Stereoselectivity of Drug-Receptor InteractionsBiological Consequences of Stereoselective Drug ActionThe Basis of StereoselectivityStereoselectivity of Drug ClassesRegulatory Requirements for Chiral DrugsDecision ProcessesCHIRALITY IN MEDICINAL CHEMISTRY, P.N. Patil and D.D. Miller, Ohio State University, USA and University of Tennessee, Memphis, USAHistorical Aspects Stereoselectivity of the Biosynthesis of Transmitters and Related MedicinalsAffinity and Intrinsic ActivitySteric Aspects of Drug Action at the Cholinergic Neuroeffector JunctionSteric Aspects of Drug Action at the Noradrenergic and Dopaminergic Neuroeffector JunctionConcluding RemarksSEPARATION OF CHIRAL COMPOUNDS-FROM CRYSTALLISATION TO CHROMATOGRAPHY, W.J. Lough, University of Sunderland, UKCrystallisationRussia, Israel, and NMRDerivatisationCommercialised Chiral HPLCChiral HPLC Beyond the EightiesBeyond HPLCMeeting Unfulfilled Needs?ELECTRONIC CIRCULAR DICHROISM-FUNDAMENTALS, METHODS AND APPLICATIONS, P. Salvadori, L. Di Bari, and C. Rosini, Universita di Pisa, Italy, Universita di Pisa, Italy and Universita della Basilicata a Potenza, ItalyIntroductionTowards an Understanding of Optical Activity and Related PhenomenaApplications to Structural ChemistryConclusions and Future PerspectivesCHIRALITY IN THE NATURAL WORLD: CHEMICAL COMMUNICATIONS, K. Mori, Science University of Tokyo, JapanIntroductionWhen was chirality found to be important in chemical communications?How was the utmost importance of chirality in chemical communications recognized?Current understanding of the importance of chirality in chemical communications-stereochemistry-bioactivity relationships among pheromonesThe practical importance of chirality in pheromone-based pest controlConclusionCHIRALITY IN THE NATURAL WORLD-ODOURS AND TASTES, W.A. König, Universität Hamburg, GermanyIntroductionThe Influence of Chirality on Biological ActivityThe Relationship Between Olfaction and Chemical StructureThe Relationship Between Odour and Taste and ChiralityEnantiomeric Odour Differences and their Quantitative MeasurementAnalysis of the confiGuration and Enantiomeric Composition of Volatile Chiral CompoundsStereochemical Analysis of Odorous Compounds 'Electronic nose', Sensor TechnologyConcluding RemarksCHIRALITY IN THE NATURAL WORLD: LIFE THROUGH THE LOOKING GLASS, C.J. Welch, Merck & Co. New Jersey, USA.IntroductionBackgroundSpecial Problems in the Study of Asymmetric OrganismsThe Machinery of Life: Symmetric Organisms from Asymmetric Building BlocksThe Asymmetry of MicroorganismsAsymmetry in the Plant WorldAsymmetry of InvertebratesAsymmetry of FishesAsymmetry of BirdsAsymmetry of Reptiles and AmphibiansAsymmetry of MammalsAsymmetry in HumansSome Recent Advances in the Developmental Biology of Animal AsymmetryBehavioural AsymmetrySummary and ConclusionCONCLUDING REMARKS-CHIRALITY, CHEMISTRY, THE FUTURE, The EditorsINDEX

O autorze

W.J. Lough, I.W. Wainer