Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese M

ISBN-13: 9780128031179 / Angielski / Twarda / 2015 / 408 str.

Wang, Xijun Zhang, Aihua Sun, Hui

Opis

Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future.

• Presents a practical guide for new practitioners of Chinmedomics with insights on the current use and future development of this method
• Each chapter includes an introduction, method, references to the latest literature, possible mechanisms of action and applications
• Edited by the leading experts of research related to Chinmedomics

Spis treści

Preface

1. Origin of Chinmedomics
2. Methods and protocols of Chinmedomics
3. Chinmedomics advancing drug discovery and development from Yinchenhao Tang
4. Chinmedomics approach dissects therapeutic properties of ShenQiWan acting on ShenYangXu syndrome
5. Metabolic profiling and biomarkers analysis of Jaundice syndrome
6. Metabolic profiling and biomarkers analysis of GanYuPiXU syndrome
7. Metabolic profiling and biomarkers of Yinhuang syndrome and evaluation on Yinchensini Tang
8. Metabolite profiling and biomarkers analysis of Jaundice syndrome related animal model
9. Metabolomic evaluation of hepatoprotective effect of Yinchenhao Tang and its major bioactive constituents
10. Metabolomics and proteomics elucidation on therapeutic mechanisms of geniposide
11. Metabolic profiling and potential biomarkers of ShenYinXu syndrome and therapeutic effect of Liuweidihuang Wan
12. Metabolic profiling of healthy persons treated with Liuweidihuang Wan
13. Metabolic profiling and potential biomarkers analysis of ShenYangXu syndrome
14. Metabolic evaluation of ShenQiWan nourishing ShenYangXu syndrome
15. Metabolic profiling and biomarkers analysis of XinQiXu syndrome
16. Active constituents screening based on correlation analysis between marker metabolites and absorbed constituents in Wen-Xin-Formula
17. Targeted synergism effects of the combined active constituents of Yinchenhao Tang
18. Metabolic profiling and biomarkers of type 2 diabetes and effective evaluation of Tianqi Jiangtang capsule
19. Metabolic biomarkers of alcohol liver damage and intervention effect of Yinchenhao Tang
20. Metabolic profiling and biomarkers analysis of insomnia and intervention effects of Suanzaoren decoction and its related active ingredients
21. Metabolic biomarkers of nonbacterial prostatitis and treatment evaluation of Phellodendri amurensis cortex and its main components
22. Metabolic profiling provides a system for understanding of Alzheimer's disease in rats after treatment with Kaixin San
23. Metabolic profiles delineate the effect of Shengmai San on Alzheimer's disease in rats

O autorze

Xijun Wang, PhD, is a Professor of Pharmacology of Traditional Chinese Medicine (TCM) and Vice President at Heilongjiang University of Chinese Medicine in China. Dr. Wang has published more than 150 papers in peer-reviewed journals, received the National Science and Technology Progress Award and National Technological Invention Award and holds 20 patents. His research focuses on serum Pharmacochemistry of Traditional Chinese Medicines. By integrating metabolomics with serum Pharmacochemistry of TCM Dr. Wang has developed and established the theory and research methods of Chinmedomics, whereby the clinical efficacy of TCM formulae can be measured and analyzed.